Actively Recruiting
Frontosubthalamic Networks in Parkinson's Disease.
Led by University of Oxford · Updated on 2025-04-02
20
Participants Needed
1
Research Sites
117 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The goal of this experimental study with is to understand the underlying mechanisms behind the increase in impulsivity seen in some patients that undergo deep brain stimulation of the subthalamic nucleus for Parkinson's Disease. The main questions it aims to answer are: What are the distributed network effects of deep brain stimulation to the subthalamic nucleus? How does this correlate with increased impulsivity? Can alternative stimulation settings be used to minimize these? Participants will complete decision-making tasks whilst their deep brain stimulation devices are turned on and off with simultaneous magnetoencephalography recordings (a type of non-invasive brain scan that measures brain activity in real-time)
CONDITIONS
Official Title
Frontosubthalamic Networks in Parkinson's Disease.
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Willing and able to give informed consent for participation
- Male or female aged 18 years or older
- Diagnosed with Parkinson's Disease and implanted with subthalamic nucleus electrodes for DBS alongside dopamine replacement therapy
- Diagnosed with or without impulse control disorders since Parkinson's diagnosis
- Willing and able to sit in the MEG scanner and follow instructions
- Willing and able to delay morning dopamine replacement therapy dose for up to four hours during the experiment
You will not qualify if you...
- Significant language barrier preventing understanding of study purpose or instructions, even with interpreter
- Presence of other implanted medical devices causing artefacts in MEG recordings
- History of other neurological disorders
- Currently enrolled in another neurological disorder clinical trial that could interfere with results
- Unable to sit still in MEG scanner for the study duration, such as due to chronic pain or osteoarthritis
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
John Radcliffe Hospital
Oxford, United Kingdom, OX39DU
Actively Recruiting
Research Team
J
John Eraifej, BSc MBChB MRCS
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
TRIPLE
Allocation
NON_RANDOMIZED
Model
PARALLEL
Primary Purpose
BASIC_SCIENCE
Number of Arms
2
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