Actively Recruiting
Fructose Intestinal Gluconeogenesis
Led by Touro University, California · Updated on 2026-03-06
40
Participants Needed
1
Research Sites
221 weeks
Total Duration
On this page
Sponsors
T
Touro University, California
Lead Sponsor
N
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Collaborating Sponsor
AI-Summary
What this Trial Is About
This study will test the hypothesis that within a defined range of fructose intake, the ability to convert fructose to glucose (via gluconeogenesis) in the small intestine plays a protective role for the liver, shielding it from the deleterious effects of fructose. We will investigate whether this protective effect of the intestine is impaired in individuals with obesity.
CONDITIONS
Official Title
Fructose Intestinal Gluconeogenesis
Who Can Participate
Eligibility Criteria
You may qualify if you...
- BMI 30 to 38 kg/m2 (obese group) or BMI 19 to 25 kg/m2 (lean group)
You will not qualify if you...
- Pregnancy or breastfeeding within the past six months
- Type 1 or 2 diabetes mellitus (including fasting glucose 65126 mg/dL, HgbA1c 656.5%)
- History of liver disease or AST and ALT more than twice the upper limit of normal
- Fasting triglyceride greater than 300 mg/dl
- Total cholesterol levels above the 95th percentile for age and sex
- Hemoglobin less than 12.5 g/dL or hematocrit less than three times the hemoglobin value
- Reported HIV or hepatitis B or C infection
- History of cancer except basal cell or squamous cell carcinoma
- Kidney disease stage 3 or higher or currently on dialysis
- Use of any anti-diabetic or cholesterol-lowering medications in the past six months
- History of surgical procedures for obesity
- Change in body weight greater than 5% in the past six months
- History of conditions affecting insulin sensitivity and lipid metabolism (e.g., polycystic ovary syndrome)
- History of galactosemia or hereditary fructose intolerance
- Positive test for fructose malabsorption at screening
- Known intolerance to acetaminophen
AI-Screening
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Trial Site Locations
Total: 1 location
1
Touro University California
Vallejo, California, United States, 95492
Actively Recruiting
Research Team
S
Sally Chiu, PhD
CONTACT
L
Lisa Johnson, RN
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
TRIPLE
Allocation
RANDOMIZED
Model
CROSSOVER
Primary Purpose
BASIC_SCIENCE
Number of Arms
4
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