Actively Recruiting
Full 3D Eye Modeling in the Diagnosis and Treatment of Lens Diseases With Eye Structures Disorders
Led by Second Affiliated Hospital, School of Medicine, Zhejiang University · Updated on 2026-01-07
1200
Participants Needed
1
Research Sites
313 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
In patients with complex cataracts, spatial abnormalities in the lens and its surrounding tissues-including both the anterior and posterior ocular segments-are often present. Due to the lack of precise preoperative assessment tools and standardized surgical protocols, these cases are associated with increased surgical complexity and difficulty, often leading to suboptimal visual outcomes. Therefore, this study explores a three-dimensional reconstruction method for the anterior segment based on swept-source optical coherence tomography (SS-OCT). By integrating imaging data from CT, B-scan ultrasound, and ultrasound biomicroscopy (UBM), a full three-dimensional model of the eye is constructed to enable objective and quantitative evaluation of its entire structure. This approach aims to provide valuable reference for surgical planning and prognostic assessment in lens diseases accompanied by ocular spatial structural abnormalities.
CONDITIONS
Official Title
Full 3D Eye Modeling in the Diagnosis and Treatment of Lens Diseases With Eye Structures Disorders
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Diagnosed with lens disorders like lens subluxation or deformity combined with conditions such as megalocornea, microcornea, nanophthalmos, keratoconus, or iris coloboma
- Ability to cooperate with and complete examinations including B-scan ultrasound, UBM, and anterior segment SS-OCT
- Diagnosed with previous or stabilized corneal trauma, traumatic cataract, or iris injury, with or without vitreous or retinal damage
- Managed open globe injuries with closed wounds and no endophthalmitis
- Patients who have undergone cataract extraction with intraocular lens implantation and have stable IOL position
- Patients with iris morphological or positional abnormalities from uveitis, trauma, or developmental anomalies
- Patients with posterior segment vitreoretinal diseases with or without anterior segment abnormalities
- No significant structural ocular diseases for normal control group
- Healthy fellow eyes of unilateral ocular trauma patients with no notable abnormalities
- Able to complete relevant imaging examinations including CT where applicable
You will not qualify if you...
- Concurrent open globe injury or severe ocular deformity
- Excessive corneal opacity or severe edema affecting image quality
- Severe dry eye or tear film abnormalities affecting imaging
- Severe ocular structural deformity preventing 3D model reconstruction
- Severe systemic disease preventing tolerance of examinations
- Contraindications to B-scan ultrasound, UBM, or CT imaging, including allergies to coupling gel or contrast medium
- Unmanaged open globe injury or severe ocular deformity for trauma patients
- Unclear or unstable intraocular lens position or implantation failure
- Corneal opacity or severe pupillary abnormalities affecting imaging
- Severe global ocular deformity or hyphema preventing imaging
- History of severe ocular trauma or surgery for normal control group
- Significant retinal pathology or anterior segment disease affecting imaging quality
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Second Affiliated Hospital, Zhejiang University School of Medicine,
Hangzhou, Zhejiang, China, 310009
Actively Recruiting
Research Team
W
Wen Xu, Phd
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
6
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