Actively Recruiting
Functional Brain Network Changes in Patients Undergoing Deep Brain Stimulation for Essential Tremor
Led by The Cleveland Clinic · Updated on 2026-05-08
55
Participants Needed
1
Research Sites
248 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The purpose of this study is to collect electrophysiological data related to functional brain network changes in patients undergoing deep brain stimulation for the treatment of essential tremor. Participants will either 1) have electroencephalography (EEG) scalp electrodes placed, or 2) remain seated with their head inside of a magnetoencephalography (MEG) recording system, as resting-state and task-related data are acquired. Spontaneous electrophysiological activity will be recorded in both the eyes open and eyes closed conditions with the participant seated comfortably. These recordings will be repeated in the DBS OFF and DBS ON states, with the ON state involving specific settings identified as optimal, sub-optimal, or ineffective at achieving tremor control. They will also be repeated following the optional administration non-DBS tremor mitigation techniques, which may include one or more of the following: 1) cooling the limb, 2) oral administration of alprazolam, 3) oral consumption of ethanol (alcohol), or 4) peripheral nerve stimulation.
CONDITIONS
Official Title
Functional Brain Network Changes in Patients Undergoing Deep Brain Stimulation for Essential Tremor
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Between 30 and 80 years of age
- Ability to provide informed consent
- Clinical diagnosis of essential tremor by a movement disorders neurologist with disease duration of at least 3 years and treatment with DBS
- Clinical diagnosis of essential tremor by a movement disorders neurologist with disease duration of at least 3 years and not treated with DBS
- No known neurological disease or disorder
You will not qualify if you...
- Condition increasing risk for compliance, safety, or study outcome interference as judged by investigator
- Active psychiatric symptoms meeting DSM-IV Axis-I disorder criteria except depression or anxiety
- History of cognitive impairment meeting DSM-IV criteria for dementia
- Lack of English fluency affecting understanding of consent and study risks
- Hearing or visual impairment that prevents testing
- Motor impairment affecting test responses (e.g., orthopedic injury or disease)
- Currently taking medications with Antabuse-like effects (e.g., Flagyl, Bactrim, Tindamax) if alcohol administration is planned
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Cleveland Clinic
Cleveland, Ohio, United States, 44195
Actively Recruiting
Research Team
J
Jeffrey Negrey, MA
CONTACT
M
Madeline Porter
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
3
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here