Actively Recruiting
Functional Cure of Hepatitis B in HIV/HBV Co-infected Patients
Led by Guangzhou 8th People's Hospital · Updated on 2023-08-14
60
Participants Needed
1
Research Sites
261 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Evaluate the potential of ART combined with interferon therapy to achieve functional cure of hepatitis B in HIV/HBV co-infected patients
CONDITIONS
Official Title
Functional Cure of Hepatitis B in HIV/HBV Co-infected Patients
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 18-65 years old, gender unrestricted
- Confirmed HIV-1 infection based on China's AIDS and HIV Infection Diagnostic Criteria
- Positive hepatitis B surface antigen for more than 6 months
- At least 1 year of antiretroviral therapy prior to screening
- Currently on ART with HBsAg <1000 IU/mL, HBeAg negative, HBV DNA <100 IU/mL, CD4+ T lymphocyte count >200 cells/µL, and HIV-RNA <20 copies/mL
You will not qualify if you...
- Pregnant, nursing, planning pregnancy, or with severe mental disorders or uncontrolled epilepsy
- Co-infected with hepatitis A, C, D, or E viruses
- Having other chronic liver diseases such as autoimmune hepatitis, drug-induced hepatitis, alcoholic hepatitis, genetic metabolic liver diseases, or moderate to severe fatty liver
- Having autoimmune diseases like rheumatoid arthritis, psoriasis, or lupus
- Post organ transplant, planning organ transplant, diagnosed or suspected liver cancer or other malignant tumors, or undergoing immunosuppressive treatment
- Severe diseases of heart, lungs, kidneys, brain, retinal disorders, or uncontrolled hypertension or diabetes
- Excessive alcohol intake (average daily >40g for men, >20g for women) or drug use
- Participation in other interventional trials within the last 3 months or other conditions deemed inappropriate by researchers
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Guangzhou Eighth People's Hospital, Guangzhou Medical University
Guangzhou, Guangdong, China, 510060
Actively Recruiting
Research Team
L
Linghua Li, PhD
CONTACT
Y
Yaozu He, Master
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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