Actively Recruiting
Functional Impact of Acute Respiratory Viral Infections in Older Adults
Led by University Hospital, Grenoble · Updated on 2026-05-08
1600
Participants Needed
24
Research Sites
126 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The prevention of infectious diseases in older adults remains a major public health challenge, as acute respiratory infections are a leading cause of hospitalisation, mortality, and functional decline worldwide. Immunosenescence and environmental exposures increase susceptibility to infection and reduce vaccine effectiveness in this population. Respiratory viruses, including influenza, SARS-CoV-2, respiratory syncytial virus, and human metapneumovirus, account for a substantial share of this burden, much of which is vaccine-preventable. However, their impact on functional decline and recovery in older adults remains insufficiently characterized. This international study aims to assess the effect of hospitalization for major respiratory viral infections on loss of autonomy in individuals aged 60 years and older, to inform targeted prevention and vaccination strategies.
CONDITIONS
Official Title
Functional Impact of Acute Respiratory Viral Infections in Older Adults
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Male or female subjects aged 60 years or older
- Hospitalized in a study center for acute respiratory infection
- Confirmed positive PCR test for influenza, SARS-CoV-2, RSV, or human metapneumovirus
- Participants with co-infections with other viral or bacterial agents can be included
You will not qualify if you...
- Severe disability (ADL score ≤2 or Clinical Frailty Scale ≥7), terminal illness, or palliative care needs
- Inability to understand or complete study questionnaires due to severe stroke sequelae, complete sensory loss, advanced dementia, or similar impairments
- Refusal or inability to answer follow-up phone assessments at 3 and 6 months
- Positive test for a virus other than influenza, SARS-CoV-2, RSV, or human metapneumovirus
- Participation in another study using an investigational or unapproved medicinal product
- Protected persons under legal or medical restrictions (pregnant, breastfeeding, minors, persons deprived of liberty, under legal protection, psychiatric care not allowed)
- Individuals opposed to participating
- Staff with a hierarchical relationship to the principal investigator
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 24 locations
1
University of Rochester School of Medicine, Infectious Diseases Unit
Rochester, New York, United States, 14642
Actively Recruiting
2
University Hospital of Amiens
Amiens, France
Active, Not Recruiting
3
Melun Hospital
Melun, France
Actively Recruiting
4
Villeneuve Saint Georges Hospital
Paris, France
Active, Not Recruiting
5
University Hospital of Poitiers
Poitiers, France
Active, Not Recruiting
6
University Hospital of Reims
Reims, France
Active, Not Recruiting
7
University Hospital of Tours
Tours, France
Active, Not Recruiting
8
Klinikum Bayreuth, Klinik für Geriatrie
Bayreuth, Germany
Not Yet Recruiting
9
Abteilung Geriatrie Universitätsmedizin Göttingen, Abteilung Geriatrie
Göttingen, Germany
Not Yet Recruiting
10
Uniklinikum Jena, Klinik für Geriatrie
Jena, Germany
Not Yet Recruiting
11
Universitätsmedizin Mannheim, IV. Medizinische Klinik (Geriatrie)
Mannheim, Germany
Not Yet Recruiting
12
Klinikum Ulm, Geriatrisches Zentrum Agaplesion Bethesda
Ulm, Germany
Not Yet Recruiting
13
University of Bari, Bari
Bari, Italy
Not Yet Recruiting
14
Azienda Ospedaliero Universitaria "Renato Dulbecco", Catanzaro
Catanzaro, Italy
Not Yet Recruiting
15
ULSS 5 Polesana, Rovigo
Rovigo, Italy
Not Yet Recruiting
16
ASL 1 Imperiese, Sanremo
Sanremo, Italy
Not Yet Recruiting
17
Città di Torino, Torino
Torino, Italy
Not Yet Recruiting
18
APSS Trento, Geriatria, Trento
Trento, Italy
Not Yet Recruiting
19
ASUGI, Trieste
Trieste, Italy
Not Yet Recruiting
20
ULSS 3 Serenissima, Venice
Venice, Italy
Not Yet Recruiting
21
ULSS 9 Scaligera, Legnago, Verona
Verona, Italy
Not Yet Recruiting
22
Hospital Clínic Barcelona Servicio de Geriatría
Barcelona, Spain
Actively Recruiting
23
Hospital Universitario Ramón y Cajal. Madrid Servicio de Geriatría
Madrid, Spain
Not Yet Recruiting
24
Hospital Universitario Virgen de la Arrixaca Murcia Servicio de Geriatría
Murcia, Spain
Not Yet Recruiting
Research Team
G
Gaetan GAVAZZI, MD,PhD
CONTACT
S
Saber TOUATI, PhD
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
0
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