Actively Recruiting
Functional Lung Avoidance SPECT-guided Radiation Therapy of Lung Cancer
Led by University of Aarhus · Updated on 2026-02-24
90
Participants Needed
2
Research Sites
365 weeks
Total Duration
On this page
Sponsors
U
University of Aarhus
Lead Sponsor
W
Westmead and Blacktown Hospital, Sydney West Radiation Oncology Network, Sydney, Australia
Collaborating Sponsor
AI-Summary
What this Trial Is About
Study aims to determine if functional lung avoidance based on perfusion single photon emission (SPECT)/CT scan, improves toxicity outcomes for patients with advanced lung cancer undergoing chemo-radiotherapy. Functional avoidance implies a dose plan that takes functional distribution in the lung into account, and avoids highly functional lung volumes sparing them from radiation.
CONDITIONS
Official Title
Functional Lung Avoidance SPECT-guided Radiation Therapy of Lung Cancer
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Histologically confirmed lung cancer (small-cell or non-small cell)
- Planned radiotherapy with curative intent
- Radiation dose of 60-66 Gy in 2-Gy fractions or site-standard dose/fractionation
- Concurrent chemotherapy allowed
- Patients with oligometastatic disease treated by surgery or radiotherapy
- Receiving chemo-radiotherapy to thoracic disease with curative intent
- Adults 18 years or older who have given oral and written informed consent
You will not qualify if you...
- Receiving concurrent immunotherapy
- Previous radiotherapy to the thorax
- Presence of other uncontrolled cancers
- Any psychological, family, social, or geographic condition that may prevent compliance with the study protocol
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 2 locations
1
Sydney West Radiation Oncology Network Westmead and Blacktown Hospitals
Sydney, New South Wales, Australia, 2145
Actively Recruiting
2
Department of Oncology, Aarhus University Hospital
Aarhus, Denmark, DK-8000
Actively Recruiting
Research Team
K
Katherina Farr, MD PhD FRACP
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
TRIPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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