Actively Recruiting
Led by University of Aarhus · Updated on 2026-02-24
90
Participants Needed
2
Research Sites
52 weeks
Total Duration
U
University of Aarhus
Lead Sponsor
W
Westmead and Blacktown Hospital, Sydney West Radiation Oncology Network, Sydney, Australia
Collaborating Sponsor
Researchers are evaluating a new method called functional lung avoidance radiotherapy for patients with advanced lung cancer undergoing chemo-radiotherapy. This approach uses a special imaging scan called perfusion single photon emission (SPECT)/CT to identify and protect highly functional areas of the lung from radiation. The study aims to see if this method improves lung toxicity outcomes compared to standard radiation therapy. Participants receive either SPECT-based radiation therapy that avoids highly functional lung areas or standard CT-based radiation therapy over 5 to 6.5 weeks. Both treatments are given with curative intent and may be combined with chemotherapy. The trial is randomized and includes a comparison between the new functional avoidance approach and the usual radiation treatment. During the study, participants will be monitored for lung toxicity from 1 to 12 months after treatment. Researchers will also assess quality of life, lung symptoms reported by patients, cancer progression, survival, and tumor control. Follow-up includes regular evaluations to track these outcomes and compare the effects of the two radiation approaches over one year.
CONDITIONS
Functional Lung Avoidance SPECT-guided Radiation Therapy of Lung Cancer
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Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
Duration - 5 to 6.5 weeks
Participants receive radiation therapy for lung cancer. Those in the experimental group receive SPECT-based radiation therapy that avoids highly functional lung areas, while others receive standard CT-based radiation therapy over 5 to 6.5 weeks. Concurrent chemotherapy may be given as part of treatment.
Radiation therapy sessions over 5 to 6.5 weeks
Duration - 1 to 12 months after treatment completion
Participants are monitored for radiation-induced lung toxicity, quality of life, lung symptoms, progression, and survival after treatment completion.
Regular visits for assessments during 1 to 12 months after treatment
Total: 2 locations
1
Sydney West Radiation Oncology Network Westmead and Blacktown Hospitals
Sydney, New South Wales, Australia, 2145
Actively Recruiting
2
Department of Oncology, Aarhus University Hospital
Aarhus, Denmark, DK-8000
Actively Recruiting
K
Katherina Farr, MD PhD FRACP
Study Type
INTERVENTIONAL
Masking
TRIPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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Azza Ahmed Khalil, Eric Hau, Val Gebski...
https://pubmed.ncbi.nlm.nih.gov/34418994