Observing Brain Blood Flow and Network Changes in Adults with Moyamoya Disease During Anesthesia Using Functional MRI

What this Trial Is About

Moyamoya disease is a condition where the blood vessels at the base of the brain narrow progressively, leading to poor blood flow and the formation of abnormal vascular networks. This study focuses on adult patients with moyamoya disease undergoing surgery and aims to observe how brain blood flow, oxygen use, and brain network connectivity change under anesthesia. The goal is to better understand anesthesia management to help protect brain function and improve cognitive abilities during the surgical period. Participants in this observational study are adults with moyamoya disease scheduled for specific brain revascularization surgeries. The study uses functional Magnetic Resonance Imaging fMRI to evaluate cerebrovascular reserve and brain network connectivity before sedation, after sedation, and while maintaining controlled blood pressure. No experimental treatments are given instead, brain function changes are monitored during the perioperative period. During the study, participants undergo brain scans and electroencephalogram monitoring at multiple time points around the surgery. Researchers will measure changes in brain functional networks and track postoperative delirium up to five days after surgery. The study observes how anesthesia and blood pressure management affect brain oxygen metabolism and connectivity. Participation lasts through the surgical and immediate recovery period, providing insights into brain function under anesthesia in moyamoya disease.

Functional Magnetic Resonance-Based Observations of Brain Networks in Moyamoya Disease Patients Under Anesthesia