Actively Recruiting
Functional Magnetic Resonance Imaging in Patients With Obstructive Sleep Apnea Syndrome
Led by CHU de Reims · Updated on 2025-12-02
70
Participants Needed
1
Research Sites
226 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The obstructive sleep apnea syndrome (OSAS) involves recurrent sleep-related upper airways (UA) collapse. UA mechanical properties and neural control are altered, imposing a mechanical load on inspiration. UA collapse does not occur during wakefulness, hence arousal-dependent compensation. Experimental inspiratory loading in normal subjects elicits respiratory-related cortical activity during wakefulness. The objective of this study is to test whether awake OSAS patients would exhibit a similar cortical activity. Whether or not such cortical compensatory mechanisms have cognitive consequences would be also analyze.
CONDITIONS
Official Title
Functional Magnetic Resonance Imaging in Patients With Obstructive Sleep Apnea Syndrome
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adults aged 18 to 75 years
- Diagnosed with severe obstructive sleep apnea syndrome (AHI > 30/h) without CPAP treatment
- Non-OSAS participants with AHI < 15/h and Epworth score < 11 (no excessive daytime sleepiness)
You will not qualify if you...
- Under 18 or over 75 years old
- Left-handed individuals
- Body mass index greater than 40 kg/m²
- Presence of other sleep disorders
- Central apnea index greater than 5/h
- Current or past neurological diseases
- Respiratory diseases such as obstructive or restrictive ventilatory disorders or hypercapnia
- Contraindications to MRI (e.g., metallic foreign body, claustrophobia, pregnancy)
- Taking medications that affect MRI BOLD signals (psychotropic drugs, vasodilators, vasoconstrictors)
- Uncorrected vision or hearing impairments
- Legal protection status
- Pregnant women based on positive beta-hCG test
- Current mood episodes or psychoactive substance use disorders in the last 6 months (excluding tobacco)
- Eating disorders
- Diagnosis of bipolar disorder or current/past schizophrenia
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Chu Reims
Reims, France, 51092
Actively Recruiting
Research Team
C
Claire Launois
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NON_RANDOMIZED
Model
SINGLE_GROUP
Primary Purpose
OTHER
Number of Arms
2
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here