Actively Recruiting
Functional Magnetic Resonance Imaging Sleep Study With Auditory Stimuli
Led by National Institute of Neurological Disorders and Stroke (NINDS) · Updated on 2026-04-24
2378
Participants Needed
1
Research Sites
1563 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Background: An electroencephalogram (EEG) measures the brain s electrical activity. EEG shows that the louder the sound needed to wake a person, the deeper the person s sleep. Researchers are using functional magnetic resonance imaging (fMRI) to study people during sleep so they can view brain activity in 3D. But they still need to correlate fMRI with sound thresholds, like the EEG. Objective: To measure brain activity during sleep using fMRI and EEG. Eligibility: Healthy people ages 18 34 who can sleep on their back for several hours. Design: Participants will be screened online about their sleep and general health. At a screening visit, participants will have: Physical exam Hearing exam MRI scan. A strong magnetic field and radio waves take pictures of the brain. Participants will lie down on a bed that slides into the scanner, which is shaped like a cylinder. Participants will wear an actigraph on their wrist that records their motor activity. Participants will follow a 2-week routine. This includes regular in-to-bed and out-of-bed times and limits on alcohol, caffeine, and nicotine. During the overnight visits, participants will have: Female subjects will have a urine pregnancy test. fMRI. A coil will be placed over the head. Participants will do tasks shown on a computer screen inside the scanner. EEG. Small electrodes on the scalp will record brain waves while sleeping or doing a task in the scanner. Participants will be asked to try to sleep while researchers collect fMRI and EEG data. Participants eyes will be monitored with a video camera. Headphones will deliver sounds to wake them up throughout the night. ...
CONDITIONS
Official Title
Functional Magnetic Resonance Imaging Sleep Study With Auditory Stimuli
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Able to give informed consent
- In good general health
- Between the ages of 18 and 34 years
- Able to sleep on your back for several hours (with breaks)
You will not qualify if you...
- Have a medical condition like diabetes or uncontrolled hypertension
- Have a psychiatric or neurologic condition like depression or stroke
- Have ever had a seizure
- Have a sleep disorder like insomnia or sleep apnea
- Work night shifts
- Have metal in your body such as pacemakers, metal prostheses, or aneurysm clips that would make MRI scanning unsafe
- Are pregnant or nursing
- Drink too much caffeine (6 or more cups of coffee per day or 10 or more cups of caffeinated soda per day)
- Use too much alcohol (15 or more alcoholic beverages per week for men and 8 or more alcoholic beverages per week for women)
- Use too much nicotine (nicotine use within 30 minutes of waking)
- Are afraid of enclosed spaces
- Have known hearing problems
- Regularly use a prescription or over-the-counter drug to help you sleep or stay awake
- Are an employee, contractor, or volunteer of the Laboratory of Functional and Molecular Imaging in the National Institute of Neurological Disorders and Stroke
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
National Institutes of Health Clinical Center
Bethesda, Maryland, United States, 20892
Actively Recruiting
Research Team
S
Susan C Guttman
CONTACT
J
Jeffrey H Duyn, Ph.D.
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here