All-night functional magnetic resonance imaging sleep studies.
Thomas M Moehlman, Jacco A de Zwart, Miranda G Chappel-Farley...
https://pubmed.ncbi.nlm.nih.gov/30243817Actively Recruiting
Age: 18Years - 34Years
All Genders
Healthy Volunteers
ID02629107
An All-Night Functional Magnetic Resonance Imaging Sleep Study with Auditory Stimuli in Healthy Adults Aged 18 to 34
Led by National Institute of Neurological Disorders and Stroke (NINDS) · Updated on 2026-04-24
2378
Participants Needed
1
Research Sites
52 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are studying brain activity during sleep using both functional magnetic resonance imaging (fMRI) and electroencephalography (EEG). The goal is to measure how the brain responds to sounds that wake a person, linking brain imaging with behavioral sleep measures. This study involves healthy young adults aged 18 to 34 who can sleep on their back for several hours and aims to uncover patterns of brain activity during sleep. Participants will undergo a one-week home-monitoring period with set bedtimes and limits on alcohol, caffeine, and nicotine. They will then participate in two overnight sleep studies in an MRI scanner, including an adaptation night and a main study night separated by a washout week. During these nights, sounds will be played at increasing volumes to wake participants multiple times, while brain activity is recorded using fMRI and EEG. During the study, participants will have screening visits with physical and hearing exams and an MRI scan. They will wear a wrist device to monitor movement and be observed by video during sleep. Female participants will have urine pregnancy tests. Researchers will measure auditory arousal thresholds and brain connectivity from fMRI data during the overnight visits. The total participation involves home monitoring and two overnight study visits, with data collected on brain response to sound during sleep.
CONDITIONS
Brief Title
Functional Magnetic Resonance Imaging Sleep Study With Auditory Stimuli
Who Can Participate
Age: 18Years - 34Years
All Genders
Healthy Volunteers
Eligibility Criteria
You may qualify if you...
- Able to give informed consent
- In good general health
- Between the ages of 18 and 34 years
- Able to sleep on your back for several hours (with breaks)
You will not qualify if you...
- Have a medical condition like diabetes or uncontrolled hypertension
- Have a psychiatric or neurologic condition like depression or stroke
- Have ever had a seizure
- Have a sleep disorder like insomnia or sleep apnea
- Work night shifts
- Have metal in your body that makes MRI unsafe (e.g., pacemakers, metal prostheses, aneurysm clips)
- Are pregnant or nursing
- Drink too much caffeine (6+ cups of coffee or 10+ cups of caffeinated soda per day)
- Use too much alcohol (15+ drinks per week for men, 8+ for women)
- Use nicotine within 30 minutes of waking
- Are afraid of enclosed spaces
- Have known hearing problems
- Regularly use medication to help sleep or stay awake
- Are an employee, contractor, or volunteer of the study laboratory
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
1
2
3
Your Study Journey
Screening
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Monitoring
Duration - 1 week
Participants undergo a one-week home-monitoring period with regular in-to-bed and out-of-bed times to track sleep behavior.
Daily monitoring at home
Diagnostic Evaluation
Duration - 2 nights separated by 1 week
Participants complete two all-night functional magnetic resonance imaging (fMRI) sleep studies to assess brain activity and auditory arousal thresholds during sleep.
2 overnight visits (in-person) separated by 1 week
Long-term Monitoring
Duration - 1 week
Participants continue home monitoring during the washout period between the two overnight fMRI sleep studies.
Daily monitoring at home
Trial Site Locations
Total: 1 location
1
National Institutes of Health Clinical Center
Bethesda, Maryland, United States, 20892
Actively Recruiting
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Research Team
S
Susan C Guttman
J
Jeffrey H Duyn, Ph.D.
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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