Actively Recruiting
A Functional Near-Infrared Spectroscopy Study on Brain Activation in Stroke Patients During Mirror Movement
Led by Second Affiliated Hospital, School of Medicine, Zhejiang University · Updated on 2026-04-03
25
Participants Needed
1
Research Sites
21 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are studying brain activation patterns in stroke patients during mirror movement to understand upper limb function. This observational study focuses on patients who have had their first stroke, either cerebral infarction or cerebral hemorrhage, with specific muscle strength and muscle tone conditions. The study takes place in a hospital rehabilitation ward where patients receive detailed information and provide informed consent before participation. The study involves two types of hand movements: mirror image and healthy hand movement. In the mirror image intervention, patients place their affected hand in a mirror box and observe the reflection of the healthy hand moving, imagining the affected hand performing the same actions. In the healthy hand movement intervention, patients quickly open and grasp their healthy hand while focusing on the affected hand. The primary outcome is brain activation measured by functional near-infrared spectroscopy (fNIRS) after one week of hand function rehabilitation training. Participants will be closely monitored throughout the trial with full communication and support from the research team. The study involves observing brain activation and hand movement activity with attention to patients' questions and responses. The total participation period includes the initial week of rehabilitation training followed by assessments to measure the brain's response to the interventions.
CONDITIONS
Brief Title
A Functional Near- Infrared Spectroscopy Study on the Brain Activation Characteristics of Stroke Patients During Mirror Movement
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Diagnosed with cerebral infarction or cerebral hemorrhage by CT or MRI according to Chinese cerebrovascular disease guidelines
- First stroke occurrence
- Muscle strength of affected finger flexor and extensor muscles is grade 1 or less
- Right-handed
- Muscle tone improvement level 2 or below on the Asworth scale
- Disease duration within 6 months and condition stable
- Age between 18 and 75 years with normal or corrected vision and hearing
You will not qualify if you...
- MMSE score less than 20 or severe memory, communication, and speech comprehension disorders
- History of epilepsy
- History of stroke, traumatic brain injury, or brain tumor in the past
- Peripheral nervous system injuries other than stroke
- Visual spatial impairments such as visual field defects or unilateral neglect
- Skull defect or metal bone plates
- Unsuitable for functional near-infrared examination
- History of intracranial surgery
- Lesion areas in the cerebellum or brainstem
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
Duration - 1 week
Participants perform hand movement exercises while brain activation is measured using functional near-infrared spectroscopy (fNIRS).
1 week of hand function rehabilitation training with observational assessments
Trial Site Locations
Total: 1 location
1
The Second Affiliated Hospital of Zhejiang University School of Medicine
Hangzhou, China
Actively Recruiting
Research Team
J
Jiasheng Zhu, Bachelor's
Y
Yifei Xia, master's
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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