Actively Recruiting
Functional Outcomes in CondUction System Pacing and Right Ventricular Synchrony (FOCUS-Right)
Led by Virginia Commonwealth University · Updated on 2026-04-16
20
Participants Needed
1
Research Sites
88 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The goal of this prospective single center clinical trial is to evaluate the safety and feasibility of performing simultaneous exercise stress cardiac magnetic resonance (CPET-CMR) and cardiopulmonary exercise testing in patients with pre-existing left bundle branch area pacemakers (LBBAP) programmed to an atrial sensing mode. Measurements of right ventricular, left ventricular function, and exercise capacity will be obtained at various LBBAP programming parameters at rest and during low intensity exercise. The main aims of the study are: * Demonstrate the safety and feasibility of performing CPET-CMR in patients with pre-existing LBBAP programmed to P-synchronous ventricular pacing mode. * Generate preliminary data evaluating differences in RV function, LV function, and exercise capacity during various pacemaker programming settings.
CONDITIONS
Official Title
Functional Outcomes in CondUction System Pacing and Right Ventricular Synchrony (FOCUS-Right)
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Presence of dual chamber left bundle branch area pacemaker implantation
- Presence of anodal capture with bipolar pacing configuration as determined at implant
You will not qualify if you...
- Known history of chronotropic incompetence
- High degree or complete heart block
- Inability to tolerate non-ventilated pacing during device interrogation
- Pregnancy
- Inability to undergo MRI or supine bicycle exercise at target workload
- Presence of MRI unsafe pacemaker components
AI-Screening
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Trial Site Locations
Total: 1 location
1
Virginia Commonwealth University
Richmond, Virginia, United States, 23298
Actively Recruiting
Research Team
A
Ajay Pillai
CONTACT
M
Melissa Sears
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NON_RANDOMIZED
Model
SINGLE_GROUP
Primary Purpose
TREATMENT
Number of Arms
3
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