Actively Recruiting
Assessment of Recovery of Functional Capillary Surface Area in Patients Undergoing Balloon Pulmonary Angioplasty for Chronic Thromboembolic Pulmonary Hypertension
Led by Jewish General Hospital · Updated on 2025-09-23
40
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
This research aims to understand how much functional pulmonary capillary surface area (FCSA) is restored after balloon pulmonary angioplasty (BPA) in patients with chronic thromboembolic pulmonary hypertension (CTEPH). CTEPH results from blood clots that become organized into the walls of pulmonary arteries, causing blockage and increased pressure, which may lead to right heart failure. The study evaluates changes in FCSA before and after BPA to better understand the relationship between artery dilation and lung microvascular function. Patients undergoing BPA will have measurements taken before and after the procedure using a technique that tracks metabolism of an injected tracer peptide (3H-benzoyl Phe-Ala-Pro) passing through lung circulation. BPA mechanically opens narrowed pulmonary arteries to improve blood flow. The study includes routine hemodynamic monitoring with arterial and pulmonary artery catheters, along with injections of the tracer to assess FCSA changes. Each participant acts as their own control with measurements taken pre- and post-BPA. Participants will be monitored with systemic and pulmonary artery catheters to measure heart and lung blood flow and pressure before and after BPA. Blood samples will be collected to analyze tracer metabolism. The main outcome is the change in pulmonary functional capillary surface area within four hours after BPA. The study plans to include up to 40 patients and will assess how reopening arteries affects lung microvascular function and pulmonary pressure.
CONDITIONS
Brief Title
Functional Pulmonary Capillary Surface Area in BPA for CTEPH
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients eligible for balloon pulmonary angioplasty for chronic thromboembolic pulmonary hypertension
You will not qualify if you...
- Treatment with angiotensin-converting enzyme inhibitors or angiotensin receptor blockers
- Presence of patent foramen ovale (a heart condition) related to blood flow between heart chambers that is not closed properly by birth or later development in the heart wall structure
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
Screening and enrollment visit
Duration - Single day
Participants undergo balloon pulmonary angioplasty (BPA) to open narrow pulmonary artery segments. Measurements of pulmonary functional capillary surface area are taken before and immediately after BPA.
1 in-person treatment visit with pre- and post-procedure assessments
Duration - Up to 4 hours post-procedure
Participants are observed for changes in pulmonary functional capillary surface area and hemodynamics after BPA.
1 follow-up visit shortly after treatment
Trial Site Locations
Total: 1 location
1
David Langleben
Montreal, Quebec, Canada, H3W 2C4
Actively Recruiting
Research Team
D
David Langleben, MD
L
Lyda Lesenko, MD
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
BASIC_SCIENCE
Number of Arms
1
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