Actively Recruiting
Surveillance for Invasive Fungal Infections in Selected Hospitals in Dhaka City, Bangladesh
Led by International Centre for Diarrhoeal Disease Research, Bangladesh · Updated on 2023-11-22
800
Participants Needed
1
Research Sites
17 weeks
Total Duration
On this page
Sponsors
I
International Centre for Diarrhoeal Disease Research, Bangladesh
Lead Sponsor
C
Centers for Disease Control and Prevention
Collaborating Sponsor
AI-Summary
What this Trial Is About
This research aims to monitor and identify invasive fungal infections among hospitalized patients in Bangladesh at two major tertiary care hospitals. It highlights the significant global burden of fungal diseases, especially among immunocompromised individuals, and the lack of ongoing national surveillance systems in Bangladesh. The study addresses challenges like insufficient diagnostic capacity and aims to improve data collection and infection prevention practices. The study involves collecting various clinical samples such as respiratory specimens, blood, urine, cerebrospinal fluid, wound swabs, and biopsy tissues from patients in intensive care, general medicine, surgery wards, and post-operative care. These samples will be tested in laboratories using microscopy, staining, culture, biochemical tests, and possibly molecular or immunological methods to identify fungal pathogens like Aspergillus, Histoplasma, Candida, Pneumocystis, Cryptococcus, and Mucormycetes. Participants include hospitalized patients of all ages with immunosuppressive conditions or risk factors for fungal infections. Consent will be obtained from patients or caregivers. The study will monitor the proportion of invasive fungal pathogens identified in these patients between July 2022 and September 2026. Data collection and testing will support improved diagnosis, management, and surveillance of fungal infections in Bangladesh.
CONDITIONS
Brief Title
Fungal Surveillance in Bangladesh
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Hospitalized patients of any age and gender in tertiary-level acute care hospitals
- Have one or more risk factors such as chronic lung disease (asthma, COPD), hemodialysis, diabetes, chemotherapy or immunosuppressive drugs for 7 or more days, AIDS
- Patients at risk of healthcare-associated infections including postoperative care, urinary catheter, tracheal intubation, ventilatory support, intravenous cannula, or other invasive procedures
- Prolonged injectable antibiotic treatment for more than 7 days
- Hospitalization longer than 7 days
- History of taking steroids or antibiotics for more than 2 weeks prior to hospitalization
- Patients or caregivers providing consent
- For children under 5 years: admitted with any illness and sepsis or pneumonia features
- Children under 5 who fail to respond to injectable antibiotics or have severe acute malnutrition, recent measles, or immune suppression
- Children requiring ICU care for more than 7 days or developing late-onset hospital-associated infection
- Children with extensive thrush after long-term injectable antibiotics
- History of steroids or antibiotics for over 2 weeks prior to hospitalization
You will not qualify if you...
- History of taking antifungal drugs within 2 weeks prior to enrollment
- Not willing to give consent
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Approximately 4 years
Participants who are hospitalized and at risk for invasive fungal infections are monitored to identify invasive fungal pathogens and assess their burden in the hospital setting.
Ongoing monitoring during hospitalization and follow-up as needed
Trial Site Locations
Total: 1 location
1
International Centre for Diarrheal Disease Research, Bangladesh (icddr,b)
Dhaka, Bangladesh, 1212
Actively Recruiting
Research Team
S
Sayeeda Huq, MBBS, MIPH
T
Tanzir A Shuvo, MBBS,MPH,PhD
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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