Actively Recruiting
Fungal Surveillance in Bangladesh
Led by International Centre for Diarrhoeal Disease Research, Bangladesh · Updated on 2023-11-22
800
Participants Needed
1
Research Sites
244 weeks
Total Duration
On this page
Sponsors
I
International Centre for Diarrhoeal Disease Research, Bangladesh
Lead Sponsor
C
Centers for Disease Control and Prevention
Collaborating Sponsor
AI-Summary
What this Trial Is About
This will be an exploratory descriptive study designed to conduct surveillance for the identification of invasive fungal pathogens among hospitalized patients in Bangladesh at two tertiary care acute-level hospitals. including the Dhaka Medical College Hospital, the Dhaka Hospital of icddr,b, and the National Institute of Cancer Research Hospital (NICRH). Respiratory samples, blood, urine, cerebrospinal fluid, surgical wound infection swabs, and other samples including biopsy tissue specimens will be obtained at intensive care units, general medicine and surgery wards, post-operative care, etc. The collected specimens will be sent to the clinical microbiology laboratories of the surveillance hospitals or to the pathology laboratory (biopsy tissue specimens) to test for Aspergillus, Histoplasms, Candida, Pneumocystis, Cryptococcus, and Mucormycetes. The lab. methods will include microscopy, staining, culture, and biochemical tests mainly and if feasible then some specimens may undergo molecular or immunological methods.
CONDITIONS
Official Title
Fungal Surveillance in Bangladesh
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Hospitalized patients of any age and gender in tertiary-level acute care hospitals
- Have one or more of the following risk factors: chronic lung conditions (asthma, COPD), hemodialysis, diabetes, chemotherapy or immunosuppressive drugs for 7 days or more, AIDS
- At risk of healthcare-associated infections (e.g., postoperative care, urinary catheter, tracheal intubation, ventilatory support, intravenous cannula, other invasive procedures)
- Under prolonged injectable antibiotic treatment (more than 7 days)
- Hospitalized for more than 7 days
- History of taking steroids or antibiotics for more than 2 weeks before hospitalization
- Patients or caregivers provide consent
- For children under 5 years: admitted with any illness and have features of sepsis or pneumonia
- Children who fail to respond to injectable antibiotics or first and second line antibiotics
- Children with severe acute malnutrition or recent measles or immune suppression and fail to respond to injectable antibiotics
- Children who develop late-onset hospital-associated infections
- Children requiring ICU care for more than 7 days
- Children with extensive thrush after long-term injectable antibiotics
- Children with history of steroids or antibiotics for more than 2 weeks before hospitalization
You will not qualify if you...
- History of taking antifungal drugs within the past 2 weeks
- Not willing to give consent
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
International Centre for Diarrheal Disease Research, Bangladesh (icddr,b)
Dhaka, Bangladesh, 1212
Actively Recruiting
Research Team
S
Sayeeda Huq, MBBS, MIPH
CONTACT
T
Tanzir A Shuvo, MBBS,MPH,PhD
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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