Actively Recruiting
Fungal Ulcer Treatment Augmented With Natamycin and Cyclosporine A
Led by University of California, San Francisco · Updated on 2025-10-06
150
Participants Needed
2
Research Sites
104 weeks
Total Duration
On this page
Sponsors
U
University of California, San Francisco
Lead Sponsor
A
Aravind Eye Hospitals, India
Collaborating Sponsor
AI-Summary
What this Trial Is About
The goal of this clinical trial is to learn if adjunctive topical Cyclosporine A eye drops combined with standard of care topical Natamycin treatment improves vision outcomes in patients with fungal keratitis.
CONDITIONS
Official Title
Fungal Ulcer Treatment Augmented With Natamycin and Cyclosporine A
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients with fungal keratitis confirmed by smear or culture, any ulcer length
- Visual acuity between 20/40 (6/12) and 20/400 (3/60) at presentation
- Age 18 years or older
- Willing to participate in the study
You will not qualify if you...
- Co-infection with bacterial or viral keratitis
- Corneal perforation
- Need for therapeutic keratoplasty due to fungal keratitis
- Unwilling or unable to follow up (e.g., living too far from hospital)
- Presenting visual acuity better than 20/40 or worse than 20/400
- Taking cyclosporine at any concentration on presentation
- Visual acuity worse than 20/200 in the unaffected eye
- Pregnancy
- History of penetrating keratoplasty
- Using topical steroids within 0-7 days before presentation
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 2 locations
1
University of California, San Farncisco
San Francisco, California, United States, 94143
Not Yet Recruiting
2
Aravind Eye Institute
Pondicherry, Tamil Nadu, India, 605 007
Actively Recruiting
Research Team
G
Gerami D Seitzman, MD
CONTACT
T
Thomas Lietman, MD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
QUADRUPLE
Allocation
RANDOMIZED
Model
FACTORIAL
Primary Purpose
TREATMENT
Number of Arms
3
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