Study of Walking and Upper Limb Movement in Adults With Neurological or Metabolic Conditions Using a Wearable Device

What this Trial Is About

Researchers are studying adult patients with neurological or metabolic diseases that affect movement, including neuromuscular disorders and obesity, to better understand how these conditions impact motor function over time. This observational study aims to collect detailed real-world data to develop reliable digital measures for future clinical trials. It is conducted at the Centre de Rfrence Ligeois des Maladies Neuromusculaires in Lige, Belgium, and involves 300 ambulant patients who can walk at least 10 meters without assistance. Participants will wear the Syde device, a wearable sensor worn on the wrist or ankle, to continuously monitor their motor activity in daily life for up to two years. Clinical assessments, such as timed walking and stair-climbing tests, muscle strength measurements, and motor function evaluations, will be performed every six months. Patients with diseases affecting the neuromuscular junction will be followed for six months. The study also includes patient questionnaires to capture their impressions of change. Throughout the study, researchers will compare continuous data from the Syde device with traditional clinical tests and questionnaires. They will monitor adherence to device use and evaluate various motor function scales. The main outcome measured every six months is the 95th centile of stride velocity. This approach aims to create meaningful digital endpoints that can enhance future therapeutic research. The total study duration varies by disease type but can last up to two years per participant.

Gait Analysis Parameter and Upper Limb Evaluation in Adult Patients With Neurological or Metabolic Pathology