Actively Recruiting

Age: 60Years - 85Years
All Genders
Healthy Volunteers
ID03020381

Gait as Predictor of Cognitive Decline, Dementia, and Risk of Falls in Mild Cognitive Impairment: A Long-Term Cohort Study

Led by Manuel Montero Odasso · Updated on 2023-12-21

600

Participants Needed

1

Research Sites

N/A

Total Duration

On this page

AI-Summary

What this Trial Is About

Researchers are studying older adults aged 60 to 85 to understand how changes in walking patterns combined with thinking difficulties may predict the risk of developing dementia and experiencing falls. The study aims to find simple and reliable ways to identify individuals with mild cognitive impairment (MCI) who are at higher risk of progressing to dementia. This research is important because dementia and falls often occur together in older adults, leading to disability, reduced quality of life, and increased healthcare costs in Canada. This long-term observational study began in 2007 and plans to follow about 600 participants over 25 years to track changes in cognition, walking, and balance. Assessments were done every 6 months for the first five years and then yearly, with additional virtual check-ins every six months starting in 2023. Participants undergo cognitive tests, gait and balance evaluations, blood tests for genetic markers, and brain imaging scans at multiple time points to monitor brain structure and function. During the study, participants will complete regular visits for cognitive and physical assessments, blood collection, and MRI scans. Researchers will track outcomes such as progression to dementia, type of dementia, mobility decline, incidence of falls, brain anatomical changes, and mortality. The study aims to identify early signs of decline to help target interventions that may delay dementia and reduce disability in older adults.

CONDITIONS

Brief Title

Gait as Predictor of Dementia and Falls. The Gait and Brain Cohort Study

Who Can Participate

Age: 60Years - 85Years
All Genders
Healthy Volunteers

Eligibility Criteria

Eligible

You may qualify if you...

  • Aged 60 to 85 years
  • Absence of dementia based on DSM IV-TR or DSM V criteria
  • Able to walk independently for 10 meters without using any walking aid (such as a walker or cane)
Not Eligible

You will not qualify if you...

  • Unable to understand English
  • Diagnosis of Parkinsonism or any neurological disorder causing lasting motor problems (e.g., stroke, epilepsy)
  • Musculoskeletal disorders affecting walking ability
  • Active osteoarthritis affecting the lower limbs
  • Use of psychotropic medications that affect movement (e.g., neuroleptics, benzodiazepines)
  • Severe depression with a score greater than 12 on the Geriatric Depression Scale

AI-Screening

AI-Powered Screening

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Your Study Journey

Screening

Duration - 2 to 4 weeks

Participants are screened for eligibility to participate in the trial.

1 visit (in-person)

Diagnostic Evaluation

Duration - Baseline visit

Participants undergo baseline assessments including blood tests for genotyping, cognitive, gait, and balance evaluations, and brain imaging (MRI).

1 baseline visit (in-person)

Long-term Monitoring

Duration - Up to 25 years

Participants are followed over 25 years to monitor cognitive function, gait, balance, and brain changes, with assessments at regular intervals.

Every 6 months for the first 5 years, then annually for up to 20 more years. Virtual assessments every 6 months after 2023.

Trial Site Locations

Total: 1 location

1

Gait and Brain Lab, Parkwood Institute

London, Ontario, Canada, N6C 0A7

Actively Recruiting

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Research Team

D

Dr. Manuel Montero Odasso, MD, PhD

How is the study designed?

Study Type

OBSERVATIONAL

Masking

N/A

Allocation

N/A

Model

N/A

Primary Purpose

N/A

Number of Arms

3

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Published Research Related To This Trial

Mild Cognitive Impairment Affects Obstacle Negotiation in Older Adults: Results from "Gait and Brain Study".

Frederico Pieruccini-Faria, Yanina Sarquis-Adamson, Manuel Montero-Odasso

https://pubmed.ncbi.nlm.nih.gov/30317237

Do depressive symptoms affect balance in older adults with mild cognitive impairment? Results from the "gait and brain study".

Frederico Pieruccini-Faria, Susan W Muir-Hunter, Manuel Montero-Odasso

https://pubmed.ncbi.nlm.nih.gov/29653157

Polypharmacy, Gait Performance, and Falls in Community-Dwelling Older Adults. Results from the Gait and Brain Study.

Manuel Montero-Odasso, Yanina Sarquis-Adamson, Hao Yuan Song...

https://pubmed.ncbi.nlm.nih.gov/30698285

Brain Structural Correlates of Obstacle Negotiation in Mild Cognitive Impairment: Results from the Gait and Brain Study.

Frederico Pieruccini-Faria, Seyyed Mohammad Hassan Haddad, Nickolas W Bray...

https://pubmed.ncbi.nlm.nih.gov/37166343