Actively Recruiting
Gait Recovery in Patients After Acute Ischemic Stroke
Led by University Hospital Olomouc · Updated on 2022-07-29
120
Participants Needed
1
Research Sites
330 weeks
Total Duration
On this page
Sponsors
U
University Hospital Olomouc
Lead Sponsor
P
Palacky University
Collaborating Sponsor
AI-Summary
What this Trial Is About
More than 80% of ischemic stroke (IS) patients have some walking disability, which restricts their independence in the activities of daily living. Physical therapy (PT) significantly contributes to gait recovery in patients after IS. However, it remains unclear, what type of gait training is more effective and which factors may have impact on gait recovery. Two hundred fifty IS patients will be enrolled to undergo a 2-week intensive inpatient rehabilitation including randomly assigned robot-assisted treadmill gait training (RTGT) or therapist-assisted treadmill gait training (TTGT). A detailed clinical and laboratory assessment of gait quality, as well as the degree of neurological impairment, quality of life, cognition and depression will be performed in all patients during the study. We hypothesize that these variables may also affect gait recovery in patients after IS. In a randomly selected 60 enrolled patients, a multi-modal magnetic resonance imaging (MRI), including functional MRI, will be performed to assess neural correlates and additional predictors of gait recovery.
CONDITIONS
Official Title
Gait Recovery in Patients After Acute Ischemic Stroke
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Ischemic stroke confirmed by magnetic resonance imaging (MRI) with NIHSS score between 1 and 12 at enrollment
- Lower limb movement impairment with at least 1 point on the NIH Stroke Scale at enrollment
- Dependent walking status with Functional Ambulatory Category score less than 3, requiring supervision or assistance for walking
You will not qualify if you...
- Previous stroke, ischemic or hemorrhagic
- Other diseases affecting walking ability or current participation in another rehabilitation or study
- Significant ischemic heart disease or peripheral arterial disease
- Obesity with BMI 40 or higher, or weight above 110 kg
- Sensory aphasia preventing understanding as verified by a speech therapist
- Moderate or severe depression with Beck scale score above 10
- Known cognitive impairment
- Previous disability with modified Rankin Scale score 3 or higher
- Currently receiving dialysis
- Diagnosed or treated for cancer
- Other orthopedic or neurological conditions affecting lower limbs
- For fMRI subgroup: pregnancy, electronic implants (pacemaker, cochlear implant, neurostimulator), incompatible metallic implants, metallic intraocular foreign body, large tattoos, unremovable piercings, body weight over 150 kg, known claustrophobia
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
University Hospital Olomouc
Olomouc, Czechia, 77520
Actively Recruiting
Research Team
B
Barbora Kolarova, PhD
CONTACT
D
Daniel Sanak, MD, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here