Actively Recruiting
Gamma-Music Based Intervention for Mild Alzheimer's Disease
Led by Northeastern University · Updated on 2023-10-06
60
Participants Needed
1
Research Sites
260 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The study will test and refine a novel brain-stimulation tool using gamma-frequency lights coupled with self-selected music for a gamma-music-based intervention for participants with mild Alzheimer's Disease. Results will yield a gamma-stimulation protocol that reliably influences brain activity (Aim 1), is adaptive, motivating and rewarding to use (Aim 2), and will generate predictions as to who might benefit the most from gamma-MBI (Aim 3). By bridging the gap between neurostimulation and behavioral intervention by combining music therapy with gamma- band neurostimulation, the present project aims to find a sustainable intervention that delays the progression of AD.
CONDITIONS
Official Title
Gamma-Music Based Intervention for Mild Alzheimer's Disease
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Ages 55 to 90 years
- Diagnosed with mild Alzheimer's Disease (amnestic, single or multiple domain)
- Perform below education-adjusted cut-off on Logical Memory II delayed paragraph recall subscale
- Clinical Dementia Rating global score of 0.5 with memory box score of 0.5 or 1
- Mini-Mental State Examination score between 20 and 24
- Preserved instrumental activities of daily living
- Medically stable
- No significant cerebrovascular disease (Modified Hachinski Ischemic score 4)
- No significant psychiatric disorders (Geriatric Depression Scale score 10)
- No history of substance or alcohol abuse
- Stable doses of psychotropic medications for at least 3 months prior
- Amyloid positive confirmed by plasma test
- No contraindications to MRI scanning
- Have a study partner able to provide collateral information
- Hearing loss no greater than mild (<40dB) confirmed by audiogram
You will not qualify if you...
- Significant cerebrovascular disease or history of stroke
- Severe psychiatric disorders or Geriatric Depression Scale score greater than 10
- History of substance or alcohol abuse
- Unstable medication doses within 3 months prior to study
- Contraindications to MRI scanning
- Hearing loss greater than mild (>40dB) on audiogram
- Inability to provide a study partner for collateral information
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Northeastern University
Boston, Massachusetts, United States, 02115
Actively Recruiting
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
OTHER
Number of Arms
2
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