Comparing Two Feeding Methods for Infants with Severe Bronchopulmonary Dysplasia A Crossover Study of Gastric and Transpyloric Feeding

What this Trial Is About

Researchers are evaluating feeding methods for hospitalized infants with severe bronchopulmonary dysplasia BPD who also have feeding intolerance. This study aims to determine the best feeding approach by comparing continuous gastric feeding with continuous transpyloric feeding. The trial is designed as a randomized crossover study to assess respiratory status and identify the optimal feeding mode for each infant. Infants will receive two weeks of continuous gastric feeding through a tube placed in the stomach, followed by two weeks of continuous transpyloric feeding where the tube passes through the stomach into the small intestine. Each infant will experience both feeding methods in this crossover design, with a total of four weeks of feeding interventions. During the study, respiratory severity will be closely monitored using the Respiratory Severity Score over eight weeks. Participants will be assessed for respiratory status and feeding tolerance throughout the trial. The study is sponsored by Le Bonheur Childrens Hospital and involves infants born before 32 weeks gestation currently admitted to the neonatal intensive care unit NICU.

Gastric Feeding Versus Transpyloric Feeding in Infants with Severe Bronchopulmonary Dysplasia, a Crossover Study