Observational Study of Gastric Precancerous Conditions in Adults Aged 35 to 84 Undergoing Endoscopy

What this Trial Is About

Gastric cancer affects about 27,000 Americans each year and often has a poor outlook because it is usually diagnosed late, when surgery to cure the cancer is less likely to succeed. This research studies patients at higher risk for gastric cancer, including those with precancerous changes in the stomach lining, such as atrophic gastritis and intestinal metaplasia. Both patients who have symptoms like indigestion and those without symptoms but with risk factors or known precursors are included. The study is observational and recruits patients from an endoscopy unit to better understand how these precancerous conditions change over time. Participants undergo outpatient endoscopy as part of their regular care, and researchers collect samples such as blood, saliva, and stomach tissue during these procedures. The study follows patients long-term to observe changes in their stomach tissue, looking for progression or improvement of the precancerous lesions. The main focus is to track changes using specific scoring systems OLGA and OLGIM and to monitor for the development of dysplasia or cancer over at least two years. During the study, participants provide biospecimens at their initial and follow-up endoscopies. Researchers assess tissue changes histologically and monitor participants for any signs of worsening or improvement. The study may continue for multiple years, with evaluations planned at least 24 months after enrollment. This long-term follow-up helps to understand risk factors and disease progression in people with gastric precancerous conditions.

The GAstric Precancerous Conditions Study