Study of Additional Endoscopic Sutures to Improve Weight Loss After Endoscopic Sleeve Gastroplasty in Adults with Morbid Obesity

What this Trial Is About

Researchers are studying endoscopic sleeve gastroplasty ESG, a less invasive bariatric surgery technique for morbid obesity. This method involves reshaping the stomach with sutures to reduce size, offering weight loss results similar to conventional surgery but with fewer complications and reversible effects. The study aims to evaluate the benefits and costs of an endoscopic revision procedure, where additional sutures may be placed during follow-up if needed, as current data on this revision approach is limited. The study randomly assigns patients who show less than 10% total weight loss or a body mass index BMI over 30 six months after ESG into two groups. One group receives a revision with additional sutures placed during a follow-up gastroscopy, while the control group undergoes only the follow-up endoscopy without any new sutures. Both groups are monitored to assess the impact of this revision on weight loss and related health factors. Participants will have scheduled follow-up consultations and evaluations at 3, 6, 12, 18, and 24 months after the initial ESG procedure. These visits will collect data on total and excess weight loss, BMI, self-esteem, gastrointestinal quality of life, comorbidity changes, and gastric emptying before and seven months after ESG. The study includes safety monitoring and assessment of the revisions effects over two years.

Gastric Recalibration After Endoscopic Sleeve Gastroplasty