Actively Recruiting
Gastro-Intestinal Digestion and Physiology After Bariatric Surgery
Led by Universitaire Ziekenhuizen KU Leuven · Updated on 2026-01-20
51
Participants Needed
1
Research Sites
76 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The goal of this clinical trial is to characterize gastrointestinal digestion and physiology in patients after bariatric surgery, or people living with obesity. The main question it aims to answer is: what is the status of gastrointestinal digestion and physiology after bariatric surgery? Participants will have two study visits: 1) participants will undergo collection of gastrointestinal samples and 2) participants will ingest an ingestible capsule that measures multiple physiological parameters along the gastrointestinal tract.
CONDITIONS
Official Title
Gastro-Intestinal Digestion and Physiology After Bariatric Surgery
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Participants must provide voluntary written informed consent before any screening procedures
- Age between 18 and 65 years
- For patients with obesity: Body Mass Index greater than 30 kg/m2
- For patients after bariatric surgery: at least one year since Roux-en-Y gastric bypass or sleeve gastrectomy
You will not qualify if you...
- History of more than one bariatric surgery
- Waist circumference greater than 125.6 cm
- Gastrointestinal surgery within the past three months
- Presence of pacemaker, defibrillator, infusion pump, or other implanted electromedical device
- Frequent exposure to X-rays within the past year
- Swallowing disorders including dysphagia for food or pills, or any oropharyngeal or esophageal stricture
- Diagnosis of Crohn's disease or Diverticulitis
- Gastrointestinal strictures, fistulas, or physiological/mechanical obstructions
- Presence of gastric bezoar
- History of complex bowel resection or known abdominal adhesions
- Short bowel syndrome or ostomy
- Current ongoing infections
- Planned use of rectal foam/enema or treatment with adjuvant chemotherapy or radiotherapy
- Currently receiving parenteral nutrition
- Planned MRI procedure during use of the wireless capsule
- Employment in professional healthcare, military, or heavy industrial areas during the study
- Pregnancy, breastfeeding, actively trying to get pregnant, or recent childbirth within last 6 months
- Inability to discontinue medications affecting gastrointestinal transit time or pH for required periods
- Any disorder that may jeopardize participant safety or compliance as judged by the investigator
AI-Screening
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Trial Site Locations
Total: 1 location
1
Universitaire Ziekenhuizen KU Leuven
Leuven, Netherlands, 3000
Actively Recruiting
Research Team
M
Maaike De Kreek, MSc
CONTACT
B
Bart Van der Schueren, Prof. Dr.
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
3
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