Assessment of Gastrointestinal Dysfunction Using GIDS and Biomarkers in Critically Ill Patients Post-Aortic Surgery

What this Trial Is About

This research aims to study gastrointestinal dysfunction in critically ill patients undergoing aortic surgery. It seeks to understand the relationship between GI dysfunction, measured using the Gastrointestinal Dysfunction Scale (GIDS) and biomarkers like citrulline and Intestinal fatty-acid binding protein (I-FABP), with nutrition delivery and important ICU outcomes. The study recognizes the high risk of complications and mortality in these patients, emphasizing early detection to guide nutritional therapy and improve clinical results. Participants in this observational study will not receive any intervention. Instead, researchers will assess GI dysfunction using the GIDS tool and measure serum levels of citrulline and I-FABP. The study focuses on patients after elective or urgent aortic surgery requiring cardiopulmonary bypass and extended mechanical ventilation. Nutritional intake including calories and protein delivered enterally or parenterally will be monitored daily from day 0 to day 7 post-surgery. During the study, participants will be closely observed in the ICU for clinical outcomes such as infection rates, need for repeated operations, length of ICU and hospital stays, duration of mechanical ventilation, parenteral nutrition requirement, and 28-day mortality in the ICU. Data collection includes monitoring nutritional delivery and recording complications up to 90 days after surgery. The study aims to identify early signs of GI dysfunction to improve care and patient quality of life during the critical postoperative period.

Gastrointestinal Dysfunction in Aortic Surgery Patients