How soon should patients be eligible for differentiated service delivery models for antiretroviral treatment? Evidence from a retrospective cohort study in Zambia.
Lise Jamieson, Sydney Rosen, Bevis Phiri...
https://pubmed.ncbi.nlm.nih.gov/36549722Actively Recruiting
Led by Boston University · Updated on 2025-11-17
1200000
Participants Needed
1
Research Sites
52 weeks
Total Duration
B
Boston University
Lead Sponsor
B
Bill and Melinda Gates Foundation
Collaborating Sponsor
This research aims to evaluate differentiated service delivery (DSD) models for HIV treatment in high-prevalence countries, focusing on Zambia. It addresses key questions about how widely these models are offered, who is eligible, patient participation, health outcomes like viral suppression, resource use compared to traditional care, and sustainability without external support. The study is observational and analyzes existing medical record data to provide insights for future decision-making. The study collects routine medical records from electronic systems and paper charts without interacting directly with patients or providers. It compares patients enrolled in various DSD models to those receiving standard HIV care. There is no intervention administered; instead, existing data sets from the Ministry of Health and partners are analyzed to assess coverage, uptake, benefits, and costs of these service models. Participants include patients aged 15 years or older accessing HIV care within the data collection period, from any HIV transmission risk group. Researchers will review patient-months enrolled in DSD models over 6, 12, and 24 months. Since this is a data analysis study, no additional tests or visits are required. The analysis will inform on clinic efficiency, treatment outcomes, and long-term sustainability of differentiated HIV care delivery in Zambia.
CONDITIONS
Gathering Records to Evaluate Antiretroviral Treatment-Zambia (GREAT )
You may qualify if you...
You will not qualify if you...
History of severe allergic reactions to study medication Currently pregnant or breastfeeding Recent participation in another clinical trial within the last 30 days Presence of uncontrolled medical conditions that could affect safety
Complete this quick 3-step screening to check your eligibility
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Up to 24 months
Participants who undergo routine care are observed through collection of routine medical record data from electronic and paper sources.
No in-person visits; data collection from medical records
Total: 1 location
1
All clinics
Lusaka, Zambia
Actively Recruiting
S
Sydney B Rosen
B
Brooke Nichols
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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Lise Jamieson, Sydney Rosen, Bevis Phiri...
https://pubmed.ncbi.nlm.nih.gov/36549722