Actively Recruiting

Age: 15Years +
All Genders
ID04158882

Analysis of Existing Medical Record Data to Evaluate Coverage, Uptake, Benefits, and Costs of Differentiated Models of Service Delivery for HIV Treatment in Africa (Zambia)

Led by Boston University · Updated on 2025-11-17

1200000

Participants Needed

1

Research Sites

52 weeks

Total Duration

On this page

Sponsors

B

Boston University

Lead Sponsor

B

Bill and Melinda Gates Foundation

Collaborating Sponsor

AI-Summary

What this Trial Is About

This research aims to evaluate differentiated service delivery (DSD) models for HIV treatment in high-prevalence countries, focusing on Zambia. It addresses key questions about how widely these models are offered, who is eligible, patient participation, health outcomes like viral suppression, resource use compared to traditional care, and sustainability without external support. The study is observational and analyzes existing medical record data to provide insights for future decision-making. The study collects routine medical records from electronic systems and paper charts without interacting directly with patients or providers. It compares patients enrolled in various DSD models to those receiving standard HIV care. There is no intervention administered; instead, existing data sets from the Ministry of Health and partners are analyzed to assess coverage, uptake, benefits, and costs of these service models. Participants include patients aged 15 years or older accessing HIV care within the data collection period, from any HIV transmission risk group. Researchers will review patient-months enrolled in DSD models over 6, 12, and 24 months. Since this is a data analysis study, no additional tests or visits are required. The analysis will inform on clinic efficiency, treatment outcomes, and long-term sustainability of differentiated HIV care delivery in Zambia.

CONDITIONS

Brief Title

Gathering Records to Evaluate Antiretroviral Treatment-Zambia (GREAT )

Who Can Participate

Age: 15Years +
All Genders

Eligibility Criteria

Eligible

You may qualify if you...

  • 15 years of age or older
  • Patients accessing care for HIV within the data collection period
  • Patients from any HIV transmission risk group
Not Eligible

You will not qualify if you...

History of severe allergic reactions to study medication Currently pregnant or breastfeeding Recent participation in another clinical trial within the last 30 days Presence of uncontrolled medical conditions that could affect safety

AI-Screening

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Your Study Journey

Screening

Duration - 2 to 4 weeks

Participants are screened for eligibility to participate in the trial.

1 visit (in-person)

Monitoring

Duration - Up to 24 months

Participants who undergo routine care are observed through collection of routine medical record data from electronic and paper sources.

No in-person visits; data collection from medical records

Trial Site Locations

Total: 1 location

1

All clinics

Lusaka, Zambia

Actively Recruiting

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Research Team

S

Sydney B Rosen

B

Brooke Nichols

How is the study designed?

Study Type

OBSERVATIONAL

Masking

N/A

Allocation

N/A

Model

N/A

Primary Purpose

N/A

Number of Arms

2

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Published Research Related To This Trial

How soon should patients be eligible for differentiated service delivery models for antiretroviral treatment? Evidence from a retrospective cohort study in Zambia.

Lise Jamieson, Sydney Rosen, Bevis Phiri...

https://pubmed.ncbi.nlm.nih.gov/36549722