Actively Recruiting
The GBA Multimodal Study in Parkinson's Disease
Led by Pacific Parkinson's Research Centre · Updated on 2025-05-31
25
Participants Needed
3
Research Sites
347 weeks
Total Duration
On this page
Sponsors
P
Pacific Parkinson's Research Centre
Lead Sponsor
U
University of British Columbia
Collaborating Sponsor
AI-Summary
What this Trial Is About
This study plans to analyze the molecular and clinical mechanisms of the relationship between the GBA mutations and Parkinson's disease. This will be assessed through the use of advanced neuroimaging techniques called PET (positron emission tomography) to study the accumulation of the tau protein and the dysfunction of acetylcholine and dopamine in the brain of people with a mutation in the GBA gene, with and without Parkinson's disease. The ingestigators will also use a technology-based assessment to study the typing patterns as possible biomarkers of early motor dysfunctions.
CONDITIONS
Official Title
The GBA Multimodal Study in Parkinson's Disease
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Heterozygous for a pathogenic GBA mutation or polymorphism (e.g., p.L444P, p.N370S)
- Age between 18 and 80 years
You will not qualify if you...
- Presence of other neurological disorders
- Having implants that prevent MRI scanning (e.g., pacemaker, ferromagnetic devices)
- Severe claustrophobia
- Intolerance to stopping antiparkinsonian drugs (for Parkinson's patients)
- Currently taking cholinergic drugs
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 3 locations
1
Oregon Health & Science University
Portland, Oregon, United States, 97239
Actively Recruiting
2
University of Washington
Seattle, Washington, United States, 98108-1595
Actively Recruiting
3
Pacific Parkinson's Research Centre | University of British Columbia
Vancouver, British Columbia, Canada
Actively Recruiting
Research Team
J
Jessamyn McKenzie
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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