Study of How Delta-9-Tetrahydrocannabinol Affects Men and Women Differently in Healthy Adults Aged 18 to 55

What this Trial Is About

Researchers are studying the acute effects of cannabinoids, specifically Delta-9-Tetrahydrocannabinol THC, in healthy adults to understand how these effects differ between women and men. This Phase 1 trial aims to explore the potential underlying mechanisms that might explain gender-related differences in response to THC. Participants receive either an active dose of THC 0.015 mgkg administered intravenously over 10 minutes or a placebo consisting of a small amount of alcohol a quarter teaspoon given intravenously with no THC, also over 10 minutes. The study is randomized and uses quadruple masking to maintain objectivity in evaluating the effects. During the study, researchers assess the rewarding effects of THC using a Visual Analog Scale at multiple time points after the infusion begins, including baseline, 10, 80, and 200 minutes. Additionally, verbal learning is evaluated using the Rey Auditory Verbal Learning Test 25 minutes post-infusion. The trial includes healthy volunteers aged 18 to 55 years, and participation involves monitoring these cognitive and subjective effects of THC.

Gender Related Differences in the Acute Effects of Delta-9-Tetrahydrocannabinol in Healthy Humans