Study of How Young Adult and Older Skin Reacts to UVB Sunlight and Insulin-Like Growth Factor 1 Treatment

What this Trial Is About

Researchers are exploring how artificial sunlight, specifically ultraviolet B radiation UVB, affects the skin of young adults compared to older adults. The study focuses on understanding why skin cancer is more common in older skin, which may be due to differences in a protein called insulin-like growth factor-1 IGF-1. Young skin has higher levels of IGF-1, while geriatric skin has very little. This research aims to see if injecting IGF-1 into older skin can make it respond more like young skin when exposed to UVB. Participants will have small skin areas exposed to UVB to study the skins reaction. Some areas will receive injections of IGF-1, while others will get saline injections as a comparison. After injection, these areas will also be treated with UVB to observe changes. This study includes young adults and geriatric adults and compares their skin responses with or without IGF-1 treatment. During the study, researchers will monitor gene expression changes that protect skin cells from UVB damage, measured two days after treatment. Participants skin responses will be closely examined to understand the effects of IGF-1 injection. The study involves no blinding or randomization, and healthy volunteers with specific skin types and ages will be enrolled. The total duration for assessing the primary outcome is two days post-treatment.

Gene Expression Changes In Young and Geriatric Skin