Comparing General and Local Anesthesia for Endovascular Treatment of Unruptured Intracranial Aneurysm Using Flow Diverter A Randomized Trial

What this Trial Is About

Researchers are investigating the safety and effectiveness of two anesthesia methods, general anesthesia GA and local anesthesia LA, in patients with unruptured intracranial aneurysm UIA undergoing flow diverter FD placement. UIA is a condition affecting 2%-7% of the population, and rupture can lead to high rates of disability and death. Although FD placement under GA is common, some studies suggest LA might be feasible with fewer complications, but these studies have limitations. This trial aims to provide more reliable evidence by comparing GA and LA in a randomized controlled design. Participants will be randomly assigned to one of two groups. The LA group will receive local anesthesia only at the femoral artery puncture site without sedation drugs. The GA group will receive local anesthesia plus fast-induction general anesthesia involving tracheal intubation or laryngeal mask insertion with medications like isoproterenol, remifentanil, and muscle relaxants. The study will closely monitor the procedure and anesthesia effects during and after the intervention. During the study, participants will be followed for 90 days after the FD placement. Researchers will assess neurological status, cognitive function, newly developed cerebral ischemic areas, complication rates, mortality, pain levels, anesthesia and operative times, vasospasm incidence, hospitalization length, and costs. Safety and effectiveness outcomes will be carefully recorded to understand the impact of anesthesia choice on patient recovery and procedure success.

General Anesthesia vs Local Anesthesia for Endovascular Treatment in Patients With Unruptured Intracranial Aneurysm Using Flow Diverter