Actively Recruiting
Generate and Test the Reliability of a PD Model of OXT on Pupillary Hippus as a Measure of CNS Activity
Led by Wake Forest University Health Sciences · Updated on 2025-12-15
38
Participants Needed
1
Research Sites
313 weeks
Total Duration
On this page
Sponsors
W
Wake Forest University Health Sciences
Lead Sponsor
N
National Institute of Neurological Disorders and Stroke (NINDS)
Collaborating Sponsor
AI-Summary
What this Trial Is About
The purpose of this research is to evaluate the effects of oxytocin (naturally occurring hormone) given by an intramuscular (IM; into the muscle) injection, has on your parasympathetic nervous system. The parasympathetic nervous system is the part of the involuntary nervous system that is sometimes called the "rest and digest" system; the parasympathetic system conserves energy as it slightly slows the heart rate, increases intestinal and gland activity, and relaxes sphincter muscles in the gastrointestinal tract.
CONDITIONS
Official Title
Generate and Test the Reliability of a PD Model of OXT on Pupillary Hippus as a Measure of CNS Activity
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Male or female aged over 18 and under 75 years with Body Mass Index (BMI) under 40
- Generally in good health as confirmed by the Principal Investigator
- Healthy volunteers must have normal blood pressure (systolic 90-140 mmHg; diastolic 50-90 mmHg) and resting heart rate between 45-100 beats per minute without medication
- Knee arthritis patients must have normal or controlled blood pressure and resting heart rate between 45-100 beats per minute
- Female participants of child-bearing potential or less than 1 year post-menopausal must use highly effective birth control methods or abstain from heterosexual intercourse for at least one full cycle before study drug administration
You will not qualify if you...
- Allergy or significant reaction to any ingredient of Pitocin®
- Any medical or surgical condition that increases risk or affects study compliance or data quality, including active gynecologic disease with uterine bleeding
- Women who are pregnant, nursing, or have been pregnant within the last 2 years
- Individuals with neuropathy, chronic pain, diabetes mellitus, or who take benzodiazepines or daily pain medications
- Participants with eye problems, previous eye surgery, use of topical eye medications, or conditions causing tremors or excessive eye movements
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Wake Forest Baptist Health
Winston-Salem, North Carolina, United States, 27157
Actively Recruiting
Research Team
R
Regina Curry, RN
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
TRIPLE
Allocation
RANDOMIZED
Model
CROSSOVER
Primary Purpose
BASIC_SCIENCE
Number of Arms
2
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