Study of Genesis Electrical Impedance Tomography EIT in Children and Adults with Respiratory and Neuromuscular Diseases and Healthy Controls

What this Trial Is About

Researchers are evaluating the Genesis Electrical Impedance Tomography EIT imaging system to understand its use in children and adults with respiratory diseases like neuromuscular disorders and bronchopulmonary dysplasia, as well as in healthy individuals matched by age and height. This study aims to assess how EIT, which uses electrodes and does not involve radiation, can detect changes in lung ventilation during various pulmonary treatments. The study includes different groups such as premature infants with bronchopulmonary dysplasia, children and adults with neuromuscular diseases, healthy controls, and patients undergoing specific heart and lung procedures like VQ scans and cardiac catheterization. Researchers will use EIT imaging to observe lung function changes related to airway clearance and both invasive and noninvasive ventilation. Some participants will be followed longitudinally, especially premature infants. Participants will undergo EIT imaging during standard care procedures, with assessments of regional lung ventilation and perfusion over time, including measurements taken within minutes and over 24 months. The study collects data on lung conductivity and pulsatile perfusion, and tracks changes related to breathing and blood flow. The research team will monitor these measures to better understand lung function in these populations, with study participation possibly lasting up to two years.

Genesis Electrical Impedance Tomography (EIT): A Preliminary Study