Actively Recruiting
Genetic Association With Various Severities, Phenotypes and Endotypes of Asthma.
Led by Chinese University of Hong Kong · Updated on 2026-03-18
2000
Participants Needed
2
Research Sites
252 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
There is limited information on genetics associated with asthma in Chinese. An earlier meta-analysis found that ADAM33, FcεRIb, RANTES, TNF-a, ACE, b2-AR, IL-4R and IL-13 genes could be proposed as asthma susceptible genes in the Chinese population. However, given the limited number of studies, more data are required to validate these associations. Future research must address key issues such as the broad clinical variability of asthma and the underrepresentation of populations of non-European heritage. Endotype-specific SNPs and unique biological insights may be obtained by conducting GWAS/EWAS on homogeneous populations of more therapy-resistant T2-low, adult-onset, obesity-associated asthma or asthma with particular co-morbidities. The primary objective is to investigate the association between genetic polymorphisms and various severities of asthma.
CONDITIONS
Official Title
Genetic Association With Various Severities, Phenotypes and Endotypes of Asthma.
Who Can Participate
Eligibility Criteria
You may qualify if you...
- All patients with confirmed diagnosis of asthma, demonstrated by consistent history and prior tests showing variable airflow obstruction with increase in FEV1 greater than 12% or 400 mL after bronchodilator, or bronchial hyperresponsiveness when stable
- Able to provide written informed consent to participate in the study
You will not qualify if you...
- Patients currently with acute asthma exacerbation; can join study after 6 weeks post recovery
- Patients with respiratory diseases mimicking chronic airway diseases such as bronchiectasis, tuberculosis-damaged lung, endobronchial tuberculosis, or lung cancer, or with history of these conditions
- Patients currently diagnosed with pneumonia or acute bronchitis
- Control subjects must have no clinical diagnosis of asthma
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 2 locations
1
The Chinese University of Hong Kong
Hong Kong, New Territories, Hong Kong
Actively Recruiting
2
The Chinese University of Hong Kong
Hong Kong, Hong Kong
Actively Recruiting
Research Team
D
David SC Hui, MD
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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