Study Investigating Genetic and Environmental Factors in Barretts Esophagus and Esophageal Adenocarcinoma

What this Trial Is About

Researchers are conducting a comprehensive study to understand the genetic and environmental factors involved in Barretts esophagus BE and esophageal adenocarcinoma EAC. The study aims to improve biological understanding and develop better methods for detection, prognosis, prevention, and treatment of these conditions. This research center builds on existing collaborations and expertise to translate laboratory discoveries into clinical applications that can help prevent EAC and enhance patient outcomes. Participants will undergo esophageal sampling using a non-endoscopic balloon capsule device, which is swallowed and inflated to collect tissue samples from the esophagus. The collected samples are preserved for genetic and molecular analysis. Additionally, all participants will have a standard upper endoscopy EGD, with biopsies taken from targeted areas based on imaging techniques. Cases and controls will also have research brushings and biopsies from different parts of the esophagus and stomach to support comprehensive research. During the study, participants may be asked about their experience with the non-endoscopic sampling, including discomfort levels compared to the standard endoscopy. Researchers will analyze DNA and RNA markers from the collected samples within one week and evaluate the tolerability of the procedures shortly after. The study involves long-term monitoring and aims to improve the understanding and early detection of BE and EAC, with participation lasting until the study completion date in 2028.

Genetic Determinants of Barrett's Esophagus and Esophageal Adenocarcinoma