Study on How Genetic Differences Affect Muscle Damage from Exercise in Healthy Adults Aged 18 to 35

What this Trial Is About

Researchers are studying how genetic differences affect muscle damage caused by exercise in healthy adults aged 18 to 35 who are members of sports clubs affiliated with Olympic federations. The study aims to understand how variations in DNA relate to changes in plasma creatine phosphokinase CPK levels before and after muscle-damaging exercise. This research could help identify athletes more prone to muscle injury and optimize training loads. Participants will perform muscle-damaging eccentric exercise designed to induce muscle damage while researchers observe their biological responses. The study focuses on assessing genetic polymorphisms and their impact on exercise-induced muscle damage by measuring blood CPK levels at multiple time points from the day of exercise up to three days afterward. During the study, participants blood samples will be collected before exercise and at three post-exercise times to analyze CPK levels and genetic markers. Researchers will monitor the association between specific gene variations and changes in muscle damage markers. The study involves a single exercise group and includes a total of 300 participants, with all assessments conducted under medical supervision throughout the study duration.

Genetic Determinants of Exercise-Induced Muscle Damage (POLYGENDOMUS)