Completed
Genetic Studies of Stuttering
Led by National Institute on Deafness and Other Communication Disorders (NIDCD) · Updated on 2024-11-18
3044
Participants Needed
3
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
Stuttering is an abnormality in speech that affects the rhythm of speech. People who stutter know what they wish to say, but at the time are unable to say it because of involuntary repetition, unnecessary lengthening (prolongation), or early stopping (cessation). Stuttering is characterized by repetitions or prolongation of the first syllable, or silent prolongations, sometimes known as blocks. Researcher intend on studying the genetic basis for stuttering. The goal of the study is to find the genes that help cause stuttering and determine regions of the human genetic make-up (genome) that are linked to stuttering.. To do this researchers will study the patterns of inheritance in families who have had members who stutter. The study has two objectives. The first objective is to develop a large collection of DNA samples from individuals in stuttering families, that will include both members that stutter and who do not stutter. The second objective of the study will be to find out the basic combination of genes (genotype) making up all of the participants DNA. Once this is completed researchers hope to map out and find areas or regions of DNA that are linked to stuttering. Genetic linkage is the initial step in positional cloning, and the cloning of genes which predispose individuals to stuttering is a long term goal of this research study.\<TAB\>
CONDITIONS
Official Title
Genetic Linkage Studies of Stuttering
Who Can Participate
Eligibility Criteria
You may qualify if you...
- INCLUSION CRITERIA:
- Individuals age 8 and older.
- Individuals age 6-8 with a family history of persistent stuttering
- Have stuttering that persists for a period of 6 months or more or are a family member of that person
- For the Phase 2 imaging studies, we will be enrolling up to 25 healthy volunteers to be controls
EXCLUSION CRITERIA:
- Stuttering only as a young child (before age 5) with no other family members who stutter
- Inability to provide informed consent or have a parent/guardian to provide consent
- Development of stuttering following trauma to the central nervous system.
- Chronic medical conditions that prevent informed consent or clear evaluation of stuttering, including stroke, dementia, and degenerative neurological disease.
- Inability to travel to the NIH Clinical Center for Phase 2
You will not qualify if you...
History of severe allergic reactions to study medication Currently pregnant or breastfeeding Recent participation in another clinical trial within the last 30 days Presence of uncontrolled medical conditions that could affect safety
Trial Site Locations
Total: 3 locations
1
National Institutes of Health Clinical Center
Bethesda, Maryland, United States, 20892
Status Unknown
2
National Rehabilitation Center for Persons with Disabilities Hospital
Saitama, Japan
Status Unknown
3
NCEMB - University of Punjab
Lahore, Pakistan
Status Unknown
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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