Actively Recruiting
Genetic, Microenvironmental, and Immunological Factors in Unresectable Pancreatic Ductal Adenocarcinoma
Led by Catholic University of the Sacred Heart · Updated on 2024-02-13
250
Participants Needed
1
Research Sites
259 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Pancreatic ductal adenocarcinoma (PDAC) complexity, where genetic, stromal, and immunological factors all interact with each other, is responsible for the overall poor response of PDAC to chemotherapeutic agents, making this a lethal disease. The investigators hypothesize that: (i) dissection of genetic, stromal, and immunological factors on endoscopic ultrasound fine needle biopsy (EUS-FNB) tissue samples from unresectable PDAC patients' will allow to determine prognostic factors in this patient population; (ii) treatment response and acquisition of tumor chemotherapy resistance could be related to genetic heterogeneity between the primary and metastatic sites and alteration of the molecular profile under drug' selection pressure.
CONDITIONS
Official Title
Genetic, Microenvironmental, and Immunological Factors in Unresectable Pancreatic Ductal Adenocarcinoma
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients referred to EUS with FNB for suspected pancreatic cancer unresectable or metastatic based on imaging findings
- Availability of biopsies obtained during EUS-FNB
- Histological diagnosis of pancreatic ductal adenocarcinoma of any stage
- Patients must be fit for chemotherapy administration
- They have to express their willingness to be followed up at our pancreatic high volume centers
- Age >18 and <80 years
- Able to sign informed consent
You will not qualify if you...
- Histological diagnoses other than pancreatic ductal adenocarcinoma
- Pregnancy or lactation
AI-Screening
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Trial Site Locations
Total: 1 location
1
"Agostino Gemelli" Hospital, Catholic University of Sacred Heart
Rome, Lazio, Italy, 00168
Actively Recruiting
Research Team
A
Alberto Larghi, MD
CONTACT
C
Carolina Gualtieri
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
0
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