Study of Genetic Profiles and Clinical Outcomes in Children and Adolescents With Malignant Brain Tumors in China

What this Trial Is About

Primary malignant central nervous system CNS tumors are the second most common cancers in children, with medulloblastomas being the most frequent malignant brain tumor in childhood, mainly located in the cerebellum. This research focuses on studying the genetic and cellular characteristics of pediatric brain tumors, especially medulloblastomas, by analyzing molecular subtypes and their relation to clinical outcomes. The study aims to explore genetic predispositions and their impact on prognosis and treatment options. This observational study includes children and adolescents diagnosed with medulloblastomas and other malignant CNS tumors who are undergoing surgical tumor removal. Blood and tumor tissue samples will be collected during surgery for various advanced genetic tests such as whole genome sequencing, RNA sequencing, single-cell sequencing, and spatial transcriptomics. Samples of medulloblastomas will also be used to grow cells and create animal models to study tumor behavior and test new drug approaches. Participants will be registered after diagnosis and followed up at 3 months, 6 months, 1 year, and annually thereafter through clinic visits and phone calls. Each follow-up will include MRI scans to monitor tumor progression, relapse, or spread, as well as assessments of neurological function and quality of life. Data collected will help researchers understand how genetic features relate to patient survival and disease progression over five years.

Genetic and Molecular Risk Profiles of Pediatric Malignant Brain Tumors in China