Actively Recruiting
Genetic Risk Factor for Heat Stroke
Led by University of Iowa · Updated on 2026-04-27
200
Participants Needed
1
Research Sites
53 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The goal of this observational study is to examine the effect of the Cystic Fibrosis (CF) Carrier state on the risk for dehydration and other CF-specific fluid-and-electrolyte disorders in male and female adults. The primary aim of the study is to estimate the risk of electrolyte disorders attributable to the CF carrier state in a genotyped cohort. This will be accomplished with two smaller projects- Aim 1 and Aim 2. Aim 1 will consist of 100 CF Carriers and 100 age- and sex-matched controls. Participants in this aim will be asked to complete a Participant Info and Temperature Survey consisting of questions about race, ethnicity, medical history, and how they experience heat. Aim 2 will consist of a subset of 25 CF Carriers and 25 age- and sex-matched controls from Aim 1. Participants in this aim will be scheduled for a visit to complete a heat challenge. At this visit, they will also complete the Participant Info and Temperature Survey. They will also sit in a sauna at 62 - 63 degrees Celsius for 45 minutes.
CONDITIONS
Official Title
Genetic Risk Factor for Heat Stroke
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Previously genotyped as a CF carrier or control
- Comfortable speaking and reading English
You will not qualify if you...
- Previously genotyped as a CF patient
- Diagnosis of Type 1 or Type 2 diabetes
- History of heart attack, stroke, heart failure, or atherosclerosis
- Currently pregnant
- Currently taking beta blockers or diuretics
- Prisoner status
- Unable to provide own written informed consent
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
University of Iowa Health Care
Iowa City, Iowa, United States, 52242
Actively Recruiting
Research Team
A
Aaron Miller, PhD
CONTACT
S
Shelby L Francis, PhD
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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