Observational Study on Heat Stroke Risk and Electrolyte Changes in Adults with Cystic Fibrosis Carrier Status

What this Trial Is About

This observational study examines how being a carrier of Cystic Fibrosis CF affects the risk of dehydration and other fluid and electrolyte problems related to CF in adults. The study focuses on estimating the risk of electrolyte disorders linked to the CF carrier state by comparing CF carriers with matched controls based on age and sex. The study has two parts. In Aim 1, 100 CF carriers and 100 matched controls will complete a survey about their medical history, race, ethnicity, and heat experience. In Aim 2, a smaller group of 25 CF carriers and 25 matched controls will undergo a heat challenge where they sit in a sauna at 62-63 degrees Celsius for 45 minutes while various measurements are taken. Participants will provide information through surveys and physical measurements including blood and urine samples, heart rate monitoring, body temperature, and sweat electrolyte levels. Researchers will track changes in weight, sodium, potassium, and sweat chloride during the heat challenge. Comfort and thermosensation scores will also be collected. The study aims to understand the temperature sensitivity and fluid balance in CF carriers compared to controls throughout the process.

Genetic Risk Factor for Heat Stroke