Actively Recruiting
Genetic Study of Obstructive Azoospermia
Led by Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University · Updated on 2024-05-08
300
Participants Needed
1
Research Sites
234 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
In 1% of men with infertility, obstructive azoospermia (OA) may occur in congenital absence of the vas (CAVD) or idiopathic obstructive azoospermia . Many studies have shown that the pathogenic genes of OA are CFTR and ADGRG2 genes, and the inheritance mode is autosomal recessive. Although the conventional assisted reproductive technology(PESA/TESA) can help these patients have children, male patients who carry mutations of the disease-causing genes (CFTR and ADGRG2) will also pass on their mutations to the next generation, which will increase the risk of male offspring infertility. Therefore, genetic detection of CFTR and ADGRG2 genes is very necessary for CAVD patients before assisted reproduction. Genetic diagnosis plays a key role in preventing the disease to the offspring.
CONDITIONS
Official Title
Genetic Study of Obstructive Azoospermia
Who Can Participate
Eligibility Criteria
You may qualify if you...
- No sperm found after centrifugation in two or more semen tests at least 2 weeks apart
- Normal blood FSH level
- Normal hematostatin b level
- Normal or polymorphic chromosome karyotype
- No Y chromosome microdeletion detected at main loci
- Seminal plasma biochemical fructose below normal value
- Semen pH less than 7.2
- Normal testicular size on transscrotal or transrectal ultrasound; presence or dysplasia of vas deferens and epididymis
You will not qualify if you...
- Abnormal urinary system development on ultrasound
- Absence of vas deferens, epididymis, or seminal vesicle on ultrasound
- Physical abnormalities such as cryptorchidism or tenderness of testis or epididymis
- History of genitourinary tract trauma, surgery, orchitis, epididymitis, seminal vesicle disease, or mumps
- Elevated red or white blood cells in semen routine lab tests
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
107 Yan Jiang Xi Road
Guangzhou, Guangdong, China, 510080
Actively Recruiting
Research Team
P
Ping Yuan, PhD
CONTACT
L
Liushan Ou
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
0
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