Study on Genetic Factors Affecting Risk and Severity of Listeriosis Infection

What this Trial Is About

Listeriosis is a rare and severe infection caused by the bacterium Listeria monocytogenes, mostly affecting older adults, people with weakened immune systems, and pregnant individuals. Some younger patients under 40 without known risk factors also develop serious forms, suggesting a possible genetic susceptibility. The MONALISA study is a national, ongoing case-control study initiated in 2009 to explore risk and prognosis factors of listeriosis, including genetic vulnerability. This study collects human biological samples such as blood, skin biopsy, and saliva from both patients diagnosed with listeriosis and their related volunteers. The genetic susceptibility to listeriosis is being investigated to better understand why some people develop severe or unusual forms of the infection. Volunteers related to patients may participate if a genetic susceptibility is identified in the patient. Participants provide samples and consent for genetic analysis over a period of 10 years. Researchers will identify genetic factors linked to susceptibility to listeriosis and its severe or atypical forms. The study aims to improve patient care through better treatment and prevention based on genetic findings. Participation includes providing biological samples and written consent, with ongoing observation and data collection.

Genetic Susceptibility to Listeriosis