Actively Recruiting
Genetic Susceptibility to Listeriosis - Listeria-GEN
Led by Institut Pasteur · Updated on 2025-09-19
100
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
Sponsors
I
Institut Pasteur
Lead Sponsor
I
Icahn School of Medicine at Mount Sinai
Collaborating Sponsor
AI-Summary
What this Trial Is About
Listeriosis is a rare and severe infection caused by the bacterium Listeria monocytogenes, mostly affecting older adults, people with weakened immune systems, and pregnant individuals. Some younger patients under 40 without known risk factors also develop serious forms, suggesting a possible genetic susceptibility. The MONALISA study is a national, ongoing case-control study initiated in 2009 to explore risk and prognosis factors of listeriosis, including genetic vulnerability. This study collects human biological samples such as blood, skin biopsy, and saliva from both patients diagnosed with listeriosis and their related volunteers. The genetic susceptibility to listeriosis is being investigated to better understand why some people develop severe or unusual forms of the infection. Volunteers related to patients may participate if a genetic susceptibility is identified in the patient. Participants provide samples and consent for genetic analysis over a period of 10 years. Researchers will identify genetic factors linked to susceptibility to listeriosis and its severe or atypical forms. The study aims to improve patient care through better treatment and prevention based on genetic findings. Participation includes providing biological samples and written consent, with ongoing observation and data collection.
CONDITIONS
Brief Title
Genetic Susceptibility to Listeriosis
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Microbiologically documented listeriosis (severe form, atypical form, or under 40 years old without identified co-morbidity)
- Affiliated or beneficiary of a social security system
- Provided informed and written consent
- Related volunteers defined as father, mother, siblings, children, grandparents, uncles, aunts, cousins, nephews, or nieces
- Related volunteers also affiliated or beneficiary of a social security system
- Related volunteers provided informed and written consent
You will not qualify if you...
- Inability to provide informed consent (for related volunteers)
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - 1 day
Participants provide biological samples including blood, skin biopsy, and saliva for genetic analysis to identify susceptibility to Listeriosis.
1 visit (in-person)
Duration - Up to 10 years
Participants are observed over a long period to identify genetic factors associated with Listeriosis and its severe or atypical forms.
Follow-up visits as needed
Trial Site Locations
Total: 1 location
1
Centre Médical de l'Institut Pasteur
Paris, France, 75015
Actively Recruiting
Research Team
M
Marc Lecuit
C
Caroline Charlier-Woerther
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NON_RANDOMIZED
Model
SINGLE_GROUP
Primary Purpose
BASIC_SCIENCE
Number of Arms
2
Frequently Asked Questions
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