Actively Recruiting
Genetic Susceptibility to Listeriosis
Led by Institut Pasteur · Updated on 2025-09-19
100
Participants Needed
1
Research Sites
522 weeks
Total Duration
On this page
Sponsors
I
Institut Pasteur
Lead Sponsor
I
Icahn School of Medicine at Mount Sinai
Collaborating Sponsor
AI-Summary
What this Trial Is About
Listeriosis is a rare, severe foodborne infection, responsible for severe invasive infections. It occurs in the great majority of cases in elderly patients and / or patients with comorbidities, with a deficit of innate or cellular immunity. Pregnancy is also a risk factor. The Multicentric Observational NAtional Analysis of Listeriosis and Listeria (MONALISA) is an ongoing national case-control prospective study on listeriosis implemented since 2009 to study risk and prognosis factors for listeriosis. In this cohort, which enrolled 902 patients on 1 August 2014, 7% of patients with neurolisteriosis are under 40 years of age and have no identified risk factor. Genetic susceptibility is suspected in these patients. Genetic susceptibility could also explain the inconstant development of a neurolisteriosis or fetal infection, as well as the particular severity of some infections (death, foetal loss, neurological sequelae). The aim of the study is to identify genetic susceptibility to Listeriosis.
CONDITIONS
Official Title
Genetic Susceptibility to Listeriosis
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Microbiologically confirmed listeriosis (severe form, atypical form, or patient under 40 years old without identified co-morbidity)
- Affiliated or beneficiary of a social security system
- Provided informed and written consent
- For volunteers related to patients: defined as father, mother, siblings, children, grandparents, uncles, aunts, cousins, nephews, or nieces
- Affiliated or beneficiary of a social security system
- Provided informed and written consent
You will not qualify if you...
- Inability to provide consent
AI-Screening
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Trial Site Locations
Total: 1 location
1
Centre Médical de l'Institut Pasteur
Paris, France, 75015
Actively Recruiting
Research Team
M
Marc Lecuit
CONTACT
C
Caroline Charlier-Woerther
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NON_RANDOMIZED
Model
SINGLE_GROUP
Primary Purpose
BASIC_SCIENCE
Number of Arms
2
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