Genetic Factors in Severe Rare Infections Including Viral, Bacterial, and Fungal Types An Observational Study

What this Trial Is About

Researchers are investigating why only some individuals infected with microbes develop severe infectious diseases. The study focuses on how genetic and environmental factors influence the immune response and disease severity. It explores rare and severe infections caused by viral, fungal, bacterial, and parasitic agents, aiming to better understand disease mechanisms and improve patient care. The research particularly looks at hereditary immune deficiencies that cause susceptibility to specific infections. Participants include patients with proven rare and severe infections and their relatives up to the third degree. The study collects blood samples from all participants and may include skin biopsies for some patients depending on their condition. This is an observational study without drug interventions, focusing on exploring genetic factors linked to infection susceptibility. Participants will provide informed consent and undergo sample collections such as blood draws and possibly skin biopsies. Researchers will analyze genetic data to identify chromosomal regions and candidate genes related to susceptibility to infections. The study involves long-term monitoring over approximately 10 years to validate genetic factors. Participants are monitored during hospital visits or follow-ups, with no treatment assigned by the study.

Genetic Susceptibility to Severe Infections