Studying Genetic Variants Affecting Specialized Pro-resolving Mediators and Their Link to Chronic Inflammatory and Cardiovascular Diseases

What this Trial Is About

Inflammation is the bodys response to infection, injury, or illness, but uncontrolled inflammation can lead to diseases like rheumatoid arthritis and cardiovascular conditions. Researchers are studying specialized pro-resolving mediators SPM, molecules that regulate inflammation, to see if genetic differences affect their function. This study focuses on genetic variants in enzymes and receptors related to SPM and how these might influence inflammatory diseases. The study will recruit adult volunteers from the Genes & Health program, focusing on those with specific genetic mutations and those without as controls. Participants will provide blood samples at clinical assessment centers, where trained staff will collect up to 60 ml of blood per visit, not exceeding three visits. Researchers will analyze the blood using advanced techniques to profile lipid mediators and perform cell biology tests such as phagocytosis and platelet activation assays. Participants will consent to blood donation and access to their health records to link genetic variants with inflammatory conditions. The study will measure lipid mediator profiles immediately after blood collection and follow up with additional blood cell function tests for up to six months. Risks are low, mainly related to data privacy and blood donation, with strict data protections in place. The study aims to increase understanding of inflammation mechanisms to support future treatment discoveries.

Genetic Variants and Regulation of Specialized Pro-resolving Mediator