Actively Recruiting
Identifying the Effect of Genetic Variants on Specialized Pro-resolving Mediators and Their Association With Chronic Inflammatory Conditions
Led by Queen Mary University of London · Updated on 2026-02-05
200
Participants Needed
1
Research Sites
9 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Inflammation is the body's response to infection, injury, or illness, but uncontrolled inflammation can lead to diseases like rheumatoid arthritis and cardiovascular conditions. Researchers are studying specialized pro-resolving mediators (SPM), molecules that regulate inflammation, to see if genetic differences affect their function. This study focuses on genetic variants in enzymes and receptors related to SPM and how these might influence inflammatory diseases. The study will recruit adult volunteers from the Genes & Health program, focusing on those with specific genetic mutations and those without as controls. Participants will provide blood samples at clinical assessment centers, where trained staff will collect up to 60 ml of blood per visit, not exceeding three visits. Researchers will analyze the blood using advanced techniques to profile lipid mediators and perform cell biology tests such as phagocytosis and platelet activation assays. Participants will consent to blood donation and access to their health records to link genetic variants with inflammatory conditions. The study will measure lipid mediator profiles immediately after blood collection and follow up with additional blood cell function tests for up to six months. Risks are low, mainly related to data privacy and blood donation, with strict data protections in place. The study aims to increase understanding of inflammation mechanisms to support future treatment discoveries.
CONDITIONS
Brief Title
Genetic Variants and Regulation of Specialized Pro-resolving Mediator
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Current volunteer of the Genes & Health program with or without relevant genetic mutations
- Adult aged 18 years or older
- Consent to donate blood samples for the study
- Consent to access medical and health records
You will not qualify if you...
- Volunteer who has not had genome sequencing in Genes & Health program
- Significant genetically inherited conditions
- Any abnormality or disease that might increase risk or affect study results
- Recovering from surgery
- Participation in a clinical study of new drugs or blood loss over 400 mL in last 3 months
- History or presence of drug or alcohol abuse
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Single day
Participants donate blood samples for lipid mediator profiling and cell biology assays.
Up to 3 visits for blood donation
Duration - Up to 6 months
Participants’ health records are accessed to identify associations between genetic variants and chronic inflammatory conditions. Cellular function is assessed up to 6 months after blood sample collection.
No additional visits required
Trial Site Locations
Total: 1 location
1
Queen Mary University of London
London, United Kingdom, EC1M 6BQ
Actively Recruiting
Research Team
E
Esteban A Gomez Cifuentes, PhD student
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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