Actively Recruiting
Genetic Variation in IgG in Alpha 1 Antitrypsin Deficiency
Led by University of Alabama at Birmingham · Updated on 2025-11-10
30
Participants Needed
1
Research Sites
90 weeks
Total Duration
On this page
Sponsors
U
University of Alabama at Birmingham
Lead Sponsor
A
Alpha-1 Foundation
Collaborating Sponsor
AI-Summary
What this Trial Is About
The goal of this study is to learn whether patients who have a genetic mutation in the genes that cause alpha 1 antitrypsin deficiency also have genetic variation in nearby genes that can increase risk for reduced immune function and respiratory infections. To investigate this hypothesis, we will compare immune responses to the 20-valent pneumococcal conjugate vaccine (PCV20, Pfizer) between participants who have one abnormal copy of the SERPINA1 gene and either no COPD exacerbations, vs those with 2 or more COPD exacerbations in the past year.
CONDITIONS
Official Title
Genetic Variation in IgG in Alpha 1 Antitrypsin Deficiency
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adults who have one abnormal copy of the SERPINA1 Z allele gene
- Have had either no COPD exacerbations or two or more COPD exacerbations in the past year
- Have not received a pneumococcal conjugate vaccine within the past 5 years or have only received the pneumococcal polysaccharide vaccine previously
You will not qualify if you...
- Received a pneumococcal conjugate vaccine within the past 5 years
- Have a known allergy, severe adverse reaction, or sensitivity to pneumococcal conjugate vaccines
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
University of Alabama at Birmingham
Birmingham, Alabama, United States, 35294
Actively Recruiting
Research Team
D
David LaFon, MD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
BASIC_SCIENCE
Number of Arms
1
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here