Actively Recruiting
Genetic Variation in TRAF3IP2 (rs13190932)
Led by South Valley University · Updated on 2025-07-25
50
Participants Needed
1
Research Sites
53 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Psoriasis is an immune-mediated inflammatory disease that is highly prevalent worldwide, affecting approximately 2-3% of the world population. It is characterized by red, scaly plaques that can appear on various parts of the body, causing significant physical and psychological burden to affected individuals. The Pathogenesis of PsA involves a complex interplay of genetic, immunological, and environmental factors.Genetic studies have identified several susceptibility loci, including HLA-Cw6 and IL23R, which are shared with psoriasis. Additionally, the presence of certain alleles, such as HLA-B27, is associated with a more severe disease course and a higher likelihood of axial involvement.
CONDITIONS
Official Title
Genetic Variation in TRAF3IP2 (rs13190932)
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients aged 18 to 70 years
- Confirmed diagnosis of psoriasis vulgaris or psoriatic arthritis by a dermatologist or rheumatologist
- Severity of skin symptoms with PASI score between 7 and 12 (moderate) or above 12 (severe)
- Willingness to participate by signing informed consent
- Starting Methotrexate therapy for prospective cohort
- Ability and willingness to attend scheduled follow-up visits
You will not qualify if you...
- Having other autoimmune diseases such as rheumatoid arthritis or systemic lupus erythematosus
- Being pregnant or breastfeeding
- Currently receiving immunosuppressive or systemic therapies
- Having known genetic disorders affecting immune system function
- Experiencing liver or kidney impairment
- Allergy or contraindication to Methotrexate
- Having active or uncontrolled infections, including chronic infections like tuberculosis
- Previous genetic testing for TRAF3IP2 gene polymorphism (rs13190932)
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Qena Hospital
Qina, Egypt
Actively Recruiting
Research Team
F
Fawzia Mohamed Abd Elzaher, MSC
CONTACT
S
Soheir Abdel-Hamid Ali, Lecturer
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
3
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