Actively Recruiting
Genetics and Aerobic Exercise to Slow Parkinson's Disease Trial
Led by Jay Alberts · Updated on 2025-10-23
200
Participants Needed
1
Research Sites
227 weeks
Total Duration
On this page
Sponsors
J
Jay Alberts
Lead Sponsor
N
National Institutes of Health (NIH)
Collaborating Sponsor
AI-Summary
What this Trial Is About
The proposed multi-site, Genetics and Aerobic Exercise to Slow PD (GEARS) Trial will, for the first time, determine the interplay between genetics and exercise in altering PD progression. In sum, 200 PD patients will be recruited from the Cleveland and Salt Lake City metro areas to participate in the Pedaling for Parkinson's (PFP) community-based exercise program. Participants will exercise at community-based sites 3x/week for 12 months. All participants will undergo genotyping using an array that includes the genome backbone and common risk variants associated to increase risk for multiple neurological disorders including PD.
CONDITIONS
Official Title
Genetics and Aerobic Exercise to Slow Parkinson's Disease Trial
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adults diagnosed with Parkinson's disease by a physician or physician extender
- Hoehn and Yahr stage I to III
- Ability to safely mount and dismount a stationary cycle
- Reliable transportation to the community exercise facility
- Possession of a smartphone device for activity data monitoring
- On a stable dose of anti-parkinsonian medication
You will not qualify if you...
- Participation in any disease modifying Parkinson's disease clinical trial or study
- Diagnosis of dementia or neurocognitive impairment that affects ability to give informed consent
- Implanted deep brain stimulation electrodes or focused ultrasound for Parkinson's disease management
- Recommendation for medical clearance by American College of Sports Medicine Preparticipation Health Screen without obtaining clearance
- Musculoskeletal issues like arthritis, osteoporosis, or back problems limiting cycling ability
- Neurological diseases other than Parkinson's disease such as multiple sclerosis or stroke
- Current cardiac arrhythmia
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
The Cleveland Clinic
Cleveland, Ohio, United States, 44195
Actively Recruiting
Research Team
E
Elizabeth Jansen, MPH
CONTACT
A
Anson Rosenfeldt, DPT
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
TREATMENT
Number of Arms
1
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