Actively Recruiting
Genetics and Environment iNtersection In the ALS-FTD Spectrum: an Italian Twins Cohort studY With a Multi-Omics Approach
Led by Azienda Ospedaliero-Universitaria di Modena · Updated on 2025-02-04
45
Participants Needed
3
Research Sites
104 weeks
Total Duration
On this page
Sponsors
A
Azienda Ospedaliero-Universitaria di Modena
Lead Sponsor
A
A.O.U. Città della Salute e della Scienza - Molinette Hospital
Collaborating Sponsor
AI-Summary
What this Trial Is About
The goal of this study is to learn from discordant twins affected by Amyotrophic Lateral Sclerosis and/or Frontotemporal Dementia the contribution of genetic background versus environmental exposure. The main questions it aims to answer is: * How far does the genetic background explain the onset of ALS/FTD in discordant twins? * Which environmental factors and events occurring in post-fetal life influence the onset or progression of this neurodegenerative condition? Participants with ALS and/or FTD with a monozygotic or dizygotic twin willing to contribute to this research will be followed up for two years by specialized Motor Neuron Disorders centers in Italy, donating biological specimen for -omic sciences analysis, and checking out if prodromal signs/symptoms of these two conditions will develop during time.
CONDITIONS
Official Title
Genetics and Environment iNtersection In the ALS-FTD Spectrum: an Italian Twins Cohort studY With a Multi-Omics Approach
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age >18 years
- Presence of monozygotic (identical) or dizygotic (fraternal) twins in the family both willing to participate and able to provide informed consent
- At least one twin diagnosed with ALS by Gold Coast Criteria and/or with FTD by Strong et al. criteria
- Ability and willingness to comply with study procedures as outlined in the protocol
- Ability to understand and provide informed consent at screening before any study procedures
You will not qualify if you...
- Unwillingness to complete study assessments at least during baseline visit for both twins
- Unwillingness to donate biological samples collected at peripheral sites (excluding lumbar puncture) for both twins
- Women who are pregnant or breastfeeding
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 3 locations
1
Azienda Ospedaliero-Universitaria di Modena
Modena, Italy, Italy, 41125
Actively Recruiting
2
Azienda Ospedaliero-Universitaria Policlinico P. Giaccone di Palermo
Palermo, Italy, Italy, 90127
Actively Recruiting
3
Azienda Ospedaliero-Universitaria Città della Salute e della Scienza di Torino
Torino, Italy, Italy, 10126
Actively Recruiting
Research Team
J
Jessica Mandrioli, MD, Prof
CONTACT
C
Cecilia Simonini, BSc
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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