Actively Recruiting
The Genetics and Functional Basis of Inherited Platelet, White Blood Cell, Red Blood Cell, and Blood Clotting Disorders.
Led by Rockefeller University · Updated on 2025-10-20
60
Participants Needed
1
Research Sites
1291 weeks
Total Duration
On this page
Sponsors
R
Rockefeller University
Lead Sponsor
N
National Heart, Lung, and Blood Institute (NHLBI)
Collaborating Sponsor
AI-Summary
What this Trial Is About
Blood contains red blood cells, white blood cells, and platelets, as well as a fluid portion termed plasma. We primarily study blood platelets, but sometimes we also analyze the blood of patients with red blood cell disorders (such as sickle cell disease), white blood cell disorders, and disorders of the blood clotting factors found in plasma. Blood platelets are small cell fragments that help people stop bleeding after blood vessels are damaged. Some individuals have abnormalities in their blood platelets that result in them not functioning properly. One such disorder is Glanzmann thrombasthenia. Most such patients have a bleeding disorder characterized by nosebleeds, gum bleeding, easy bruising (black and blue marks), heavy menstrual periods in women, and excessive bleeding after surgery or trauma. Our laboratory performs advanced tests of platelet function and platelet biochemistry. If we find evidence that a genetic disorder may be responsible, we analyze the genetic material (DNA and RNA) from the volunteer, and when possible, close family members to identify the precise defect.
CONDITIONS
Official Title
The Genetics and Functional Basis of Inherited Platelet, White Blood Cell, Red Blood Cell, and Blood Clotting Disorders.
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Normal healthy volunteers 18 years or older, any sex, any ethnic background
- Adults and children with Glanzmann thrombasthenia or inherited platelet, white blood cell, or coagulation disorders, any sex, any ethnic background
You will not qualify if you...
- For platelet studies affected by anti-platelet therapy, use of aspirin or similar medication in the past week
- Blood donation exceeding 250 ml in the past 8 weeks or more than 2 donations in one week for healthy volunteers
- For patients with known hematocrit 65, same blood donation limits as healthy volunteers
- For patients under 18, max blood donation in 8 weeks is the lesser of 50 ml or 3 ml/kg
- For patients with hematocrit below 25 or unknown, max blood donation in 8 weeks is the lesser of 20 ml or 1 ml/kg
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Rockefeller University Hospital
New York, New York, United States, 10021
Actively Recruiting
Research Team
R
Recruitment Specialist
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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