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Studies of Interactions Among Normal and Abnormal Blood Cells and the Vessel Wall and Genetic and Functional Basis of Inherited Platelet, White Blood Cell, Red Blood Cell, and Clotting Disorders
Led by Rockefeller University · Updated on 2025-10-20
60
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
Sponsors
R
Rockefeller University
Lead Sponsor
N
National Heart, Lung, and Blood Institute (NHLBI)
Collaborating Sponsor
AI-Summary
What this Trial Is About
Researchers are studying blood disorders affecting platelets, white blood cells, red blood cells, and blood clotting factors found in plasma. The focus is on inherited platelet disorders such as Glanzmann thrombasthenia, which cause bleeding problems like nosebleeds, gum bleeding, easy bruising, heavy menstrual bleeding, and excessive bleeding after injury or surgery. The study aims to understand the genetic and functional causes of these disorders by analyzing blood samples and genetic material from patients and their families. Volunteers, including healthy individuals and patients with blood disorders or their relatives, visit the outpatient research center for detailed medical history, physical exams, and blood tests. Additional visits may be requested for further testing. If abnormalities are found, participants are advised to repeat tests in certified clinical laboratories. The study includes normal healthy volunteers aged 18 or older and patients or relatives of any age with inherited blood disorders. Participants undergo laboratory tests to evaluate platelet function, including measuring platelet aggregation time. Blood samples are collected for biochemical and genetic analysis. Researchers monitor platelet function and identify genetic defects that may cause the disorders. The study may involve follow-up visits for additional assessments. Participation involves no treatment but focuses on observation and detailed blood testing over time to better understand these inherited blood conditions.
CONDITIONS
Brief Title
The Genetics and Functional Basis of Inherited Platelet, White Blood Cell, Red Blood Cell, and Blood Clotting Disorders.
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Normal healthy volunteers 18 years of age or older of either sex and any ethnic background
- Adults and children with Glanzmann thrombasthenia or inherited qualitative and/or quantitative platelet disorders
- Adults and children with inherited disorders of white blood cells or coagulation, including von Willebrand disease
- Either sex and any ethnic background for all participant groups
You will not qualify if you...
- For platelet studies affected by antiplatelet therapy, use of aspirin or similar medication in the past week
- Blood donation within the last 8 weeks exceeding a total of 250 ml for healthy volunteers
- More than 2 blood donations in one week for healthy volunteers
- For patients with hematocrit ≥25, same blood drawing limits as healthy volunteers
- For children under 18 with hematocrit ≥25, blood donation limit is the lesser of 50 ml or 3 ml/kg in 8 weeks
- For patients with hematocrit <25 or unknown, blood donation limit is the lesser of 20 ml or 1 ml/kg in 8 weeks for patients and relatives with blood disorders
- Recent aspirin or similar medication use for patients and relatives in platelet studies affected by antiplatelet therapy
- More than 2 blood donations in one week for patients and relatives with blood disorders
- Blood donation limits based on hematocrit levels and age for patients and relatives with blood disorders according to specified volumes in 8 weeks period
- Any condition that would interfere with study participation as determined by investigators or study protocol restrictions related to blood donation and medication use in the past week for all participants with platelet studies affected by antiplatelet therapy
- Restrictions apply to both healthy volunteers and patients with inherited blood disorders regarding medication and blood donation timing and volume limits as detailed above in the exclusion criteria section for the study population with platelet function evaluations affected by antiplatelet therapy and hematocrit values as specified in the study protocol for patients and relatives with blood disorders or healthy volunteers respectively
- Any other medical or study-specific exclusion criteria as determined by the study protocol and investigators for all participant groups in the research study of inherited blood disorders and platelet function tests affected by medication and blood donation history during specified timeframes and volumes as per protocol requirements and safety considerations in the clinical trial research setting involving blood sample collections and platelet function assessments conducted by the research laboratory and outpatient research center personnel at Rockefeller University in the ongoing observational clinical research study on inherited blood disorders and platelet function abnormalities involving normal healthy volunteers, patients with inherited blood conditions, and their relatives as described in the clinical trial documentation and eligibility criteria detailed in the study protocol and research study documents at the outpatient research center and laboratory facilities for this research study conducted by Rockefeller University and principal investigators involved in the clinical research project on genetic and functional blood cell disorders and platelet function abnormalities as per the specified study protocol and inclusion/exclusion criteria for participant safety and research quality assurance and compliance with study regulations and ethical standards in clinical research involving human subjects and blood sample collection procedures for laboratory testing and genetic analyses as outlined in the clinical trial documentation and eligibility criteria summarized for participant information purposes only in this clinical research study on inherited blood disorders and platelet function abnormalities at Rockefeller University in the United States of America and under the supervision of the principal investigator and research staff as per the research protocol and study documentation requirements and ethical standards for human subject research involving blood sample collection and platelet function testing in this clinical trial research study focusing on understanding genetic and functional causes of inherited blood disorders and platelet abnormalities in affected individuals and healthy volunteers for research and knowledge advancement purposes only and not for therapeutic treatment or clinical care provision currently ongoing and registered under the identifier NCT00230165 at ClinicalTrials.gov and other clinical research registries and databases for public and scientific research transparency and participant information dissemination and recruitment purposes as described in the clinical trial official documentation and research protocol and as per the study sponsor Rockefeller University and principal investigator oversight and study staff involvement in the conduct of this clinical research study on platelet, white blood cell, red blood cell, and coagulation disorders and their genetic and functional basis and interactions with the vessel wall and blood cells in normal and affected individuals and their relatives with inherited blood disorders and platelet function abnormalities and related blood conditions and clotting disorders involving observational research and laboratory analysis at the outpatient research center and research laboratory facilities and blood sample collection and genetic testing procedures conducted as per the study design and protocol requirements and participant eligibility and safety monitoring procedures and research quality control and compliance with institutional and regulatory standards for human subjects research and clinical research ethics and good clinical practice guidelines and regulatory agency requirements for clinical research involving human participants and blood sample collection and genetic analysis for inherited blood disorders and platelet function abnormalities and related blood conditions and coagulation disorders research study conducted by Rockefeller University and principal investigator and research team at the outpatient research center and research laboratory facilities as per the study protocol and clinical research documentation and participant information materials for this clinical research study on inherited blood disorders and platelet function abnormalities and related blood conditions and coagulation disorders conducted according to clinical research standards and regulations and institutional review board approvals and ethical guidelines for human subject research in the United States of America for this ongoing observational clinical research study on genetic and functional blood cell and platelet disorders and their interactions with the vessel wall and blood components and related inherited blood disorders and coagulation abnormalities and platelet function studies and genetic analyses and laboratory testing procedures as described in the clinical trial documentation and research study protocol and eligibility requirements and exclusion criteria summary for participant safety and research quality assurance and compliance with clinical research regulations and ethical standards as per the study protocol and principal investigator oversight and research team involvement at Rockefeller University research facilities and outpatient research center and clinical research laboratory for this clinical research study on inherited blood disorders and platelet function abnormalities and related blood conditions and coagulation disorders and genetic studies and platelet aggregation and laboratory testing procedures and blood sample collection and genetic analysis and research study documentation and participant information materials for this clinical research study on inherited blood disorders and platelet function abnormalities and related blood conditions and coagulation disorders and genetic analyses and platelet function testing and laboratory procedures and blood sample collection and genetic material analysis and research study conducted by Rockefeller University and principal investigator and research team at the outpatient research center and research laboratory facilities as per the clinical research protocol and institutional review board approvals and ethical guidelines and clinical research regulations and standards for human subject research in the United States of America and as summarized in the clinical trial documentation and research study protocol and eligibility criteria information for participant information and clinical research quality assurance and compliance with clinical research regulations and ethical standards and institutional review board approvals and research team involvement in this clinical research study on inherited blood disorders and platelet function abnormalities and related blood conditions and coagulation disorders and genetic analyses and platelet function testing and laboratory procedures and blood sample collection and genetic material analysis and research study documentation and participant information materials for this clinical research study on inherited blood disorders and platelet function abnormalities and related blood conditions and coagulation disorders and genetic analyses and platelet function testing and laboratory procedures and blood sample collection and genetic material analysis and research study conducted by Rockefeller University and principal investigator and research team at the outpatient research center and research laboratory facilities as per the clinical research protocol and institutional review board approvals and ethical guidelines and clinical research regulations and standards for human subject research in the United States of America
AI-Screening
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Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Up to several months depending on testing needs
Participants provide blood samples and undergo detailed history and physical examination to study inherited blood and clotting disorders. Additional visits may be requested for further testing if abnormalities are detected.
1 to 2 visits, additional visits if needed
Trial Site Locations
Total: 1 location
1
Rockefeller University Hospital
New York, New York, United States, 10021
Actively Recruiting
Research Team
R
Recruitment Specialist
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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