Actively Recruiting
Genetics of Insulin and Incretins in Cystic Fibrosis
Led by Children's Hospital of Philadelphia · Updated on 2025-07-25
550
Participants Needed
2
Research Sites
687 weeks
Total Duration
On this page
Sponsors
C
Children's Hospital of Philadelphia
Lead Sponsor
U
University of Pennsylvania
Collaborating Sponsor
AI-Summary
What this Trial Is About
Cystic fibrosis related diabetes (CFRD) is associated with worse CF-relevant outcomes. The mechanisms underlying CFRD development are not fully understood, but recent evidence suggests Type 2 Diabetes Mellitus (T2DM) mechanisms may be involved and may involve incretins (gut secreted hormones that augment insulin secretion in response to a nutrient load). This study will examine the prevalence of Genome wide association study (GWAS)-implicated T2DM alleles (including TCF7L2) across the spectrum of glucose abnormalities in CF and will use this information to compare incretin and insulin secretion in non-diabetic children and adults with high risk and low risk alleles.
CONDITIONS
Official Title
Genetics of Insulin and Incretins in Cystic Fibrosis
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Subjects age >2 years
- Diagnosis of Cystic Fibrosis
- For subjects under 18 years, parental or guardian permission (informed consent) and if appropriate, child assent
You will not qualify if you...
- Established diagnosis of non-CFRD (cystic fibrosis related diabetes), such as type 1 diabetes
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 2 locations
1
The Children's Hopsital of Philadelphia
Philadelphia, Pennsylvania, United States, 19104
Actively Recruiting
2
The University of Pennsylvania
Philadelphia, Pennsylvania, United States, 19104
Actively Recruiting
Research Team
R
Rachel Walega
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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