Genome Analysis of Human Endogenous Retroviruses and Gut Microbiota in Children with SARS-CoV-2 Infection, Kawasaki Disease, and Other Pediatric Inflammatory Diseases

What this Trial Is About

Researchers are studying the role of Human Endogenous Retroviruses (HERVs), ancient DNA sequences, and the gut microbiota, the community of microorganisms in the digestive tract, in children with various diseases. These include Kawasaki Disease, IgA Vasculitis/Schonlein-Henoch's Purpura, SARS-CoV-2 infection, and febrile virosis. The study aims to understand if there is a link between HERV expression, gut bacteria types, and clinical symptoms in these pediatric conditions, potentially offering new insights for care and treatment. The study involves collecting blood and fecal samples from pediatric patients diagnosed with the diseases mentioned. Blood samples will be analyzed to study HERVs, while fecal samples will be used to characterize the gut microbiota. This approach will help examine how HERV activity and gut bacteria profiles may relate to disease onset, severity, and immune response in affected children. Participants will be monitored throughout the study, with assessments focusing on HERVs and gut microbiota over about one year. The main outcomes measured include the analysis of HERVs and the characterization of microbiota throughout the study period. The results may help identify markers for disease severity and guide personalized treatments and follow-up care in pediatric patients with these inflammatory and infectious conditions.

Genome Analysis of Human Endogenous Retroviruses (HERVs)(COVID19)