Genome Analysis of Human Endogenous Retroviruses (HERVs) and Gut Microbiota in Children With SARS-CoV-2 Infection, Kawasaki Disease, and Other Febrile and Inflammatory Diseases

What this Trial Is About

Researchers are studying the role of Human Endogenous Retroviruses (HERVs), ancient DNA sequences, and gut microbiota in children with various inflammatory diseases such as Kawasaki Disease, IgA Vasculitis/Schonlein-Henoch's Purpura, SARS-CoV-2 infection, and febrile virosis. The study aims to understand how HERVs and gut bacteria might influence immune responses and disease symptoms in pediatric patients. This research could provide new insights for managing and treating these conditions. The study involves collecting blood and fecal samples from children diagnosed with the listed diseases. Blood samples are analyzed to study HERVs, while fecal samples are used to characterize the gut microbiota. Patients are enrolled consecutively as they receive a diagnosis, and the study monitors changes over approximately one year to assess associations between HERVs, gut bacteria, and clinical outcomes. Participants will have evaluations including sample collection for laboratory analyses. Researchers will measure HERV activity and gut microbiota profiles to explore their links with disease manifestations. The primary outcomes focus on these analyses throughout the study period, enabling a better understanding of immune regulation in these pediatric inflammatory diseases. The study is expected to last about one year for each participant.

Genome Analysis of Human Endogenous Retroviruses (HERVs)(COVID19)