Actively Recruiting
Genomic Analysis of Families With a History of Discordant Cancers
Led by Case Comprehensive Cancer Center · Updated on 2025-09-03
150
Participants Needed
1
Research Sites
397 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The purpose of this study is to identify novel gene mutations which have contributed to significant personal and family history of cancer. Adults with and without cancer will be accrued to the study. Participants qualify to take part in this research study because someone in their family has been diagnosed with or because they themselves have a cancer diagnosis. Participants' DNA and other clinical information will be obtained from a blood sample in order to study the genetic basis of cancer and related complications. All portions in the DNA that code for proteins (i.e., the exome) will be studied. Participant DNA sample and information about family structure and family medical history and ethnic origin may also be collected to better understand this information. Clinical information will be stored and biological samples, including DNA, will be kept for up to three (3) years after collection for future. Ultimately, once identified, the role of the specific genetics changes in the development of inherited cancer(s) will be characterized.
CONDITIONS
Official Title
Genomic Analysis of Families With a History of Discordant Cancers
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Affected patients with a family history suggesting a hereditary cancer syndrome or meeting NCCN criteria for germline testing who consent to multicancer panel testing
- Affected patients with a family history of 5 or more different cancers in a 3-generation pedigree
- Unaffected family members are eligible for whole exome sequencing if at least 2 affected and 1 unaffected family members consent
You will not qualify if you...
- Unable to safely provide a blood sample for genetic testing
- Unable or unwilling to receive genetic counseling by phone, video, or in person
- Families with a known inherited high-risk cancer gene from prior genetic evaluation are not eligible for whole exome sequencing
- Families not willing to participate in standard medical genetics evaluation
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
University Hospitals Cleveland Medical Center, Case Comprehensive Cancer Center
Cleveland, Ohio, United States, 44106
Actively Recruiting
Research Team
A
Anna Mitchell, MD PhD
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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